This same year Lust and Klocman published the first metabolism study of
a case of infantile scurvy. The baby was 18 months old and the metabolic
changes were investigated during the active, convalescent, and "the
healing stage" of the disorder. This study seems to have been carefully
carried out. The fact, however, that the infant received 800 c.c. daily
of slightly-boiled milk during the active stage, and was improving at
this time, may also have had a beneficial effect on the metabolism in
respect to scurvy. The results of these writers are surprising--quite
different from what they expected or what we should have expected. They
write: "The balance of the mineral metabolism, including the total ash,
the calcium, phosphorus and chlorin during the florid stage of the
disease must be regarded not only as not damaged, compared to that of
the healthy child, but indeed as somewhat increased." "All the more
striking, on the contrary, are the results found during the stage of
convalescence. Here the balances were all markedly negative, and only
after a lapse of weeks was the tendency manifested to a return to normal
conditions." The authors regard these results as indicating a sort of
washing out of "dead material" during convalescence--of material which
had gathered during the florid stage of the disease. According to their
interpretation the disease is due, not to a primary or secondary salt
deficiency, but to a disturbance in salt elimination, and in the first
place, of a calcium excretion. This is shown by the fact that even in
the "stage of healing," when the total ash and the phosphorus balance
once more had become positive, the calcium balance nevertheless remained
somewhat negative. The metabolism of infantile scurvy, they believe, far
from showing a resemblance to rickets, manifests quite the contrary
tendency. The study of this case of infantile scurvy and that of Baumann
and Howard of a case of adult scurvy, comprise the total investigation
of the metabolism in human scurvy.
In the course of a recent discussion on rickets before the Medical
Society of Vienna, Moll states briefly that in a case of infantile
scurvy, at the height of the disease, he found a positive calcium
balance, which became poor and later negative on giving fruit juice; in
other words, a partial confirmation of the work which has just been
cited.
Public-domain text, read in full here on John Shaqi.
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