Senescence, the Last Half of LifeHall, G. Stanley (Granville Stanley)
Science
Senescence, the Last Half of Life
Hall, G. Stanley (Granville Stanley)
Geriatrics
though vastly slower, remain still deathless.
Thus life is a really unbroken continuum from its beginning to its end
and we are all connected, as it were, by direct physical participation
with the life of our progenitors. Each individual produces a few germ
cells that reach the goal of maturity and many somatic cells doomed
to death; and in the next generation each repeats the same process.
Some flagellate spores, for example, when they divide, lose only the
flagellum, which each new individual has to reproduce for itself and
this is the rudiment of the corpse that in the higher forms of life
becomes indefinitely more bulky and complex; while underneath all this
increasing punctuation by death, as it developed, the old plasmal
immortality still persists. On the other hand, all forms of fission and
agamic budding, so common a method of reproduction in plants and often
found in simpler forms of multicellular animal life, such as sponges
and coelenterates, are reminiscent of the protozoan fashion.
Thus we see that death came into the world not by reason of sin,
as theology teaches, but because of differentiation. As cells
acquired the power to produce more and more specialized organs and
functions they lost the power to reproduce the entire body and they
lost it progressively--almost in exact proportion as their power
of multiplication became specific. Thus, as we should expect, we
find in the early stages of this differentiation cells that can be
influenced toward the old general or the new and more specific powers
of reproduction. Yet back of all the fact remains that life itself is
essentially perdurable and that we can explain death better than we can
explain life. Death is thus not necessary or universal but is derived
and is, in a sense, a product of slow development; and we can conceive
a stage of evolution in which natural death did not occur at all but
was always due to external accidents. Indeed, Weismann goes so far as
to say that the difference between the germ and the soma is so great
that the latter, with all its fortunes, has little or no influence upon
the former; and by his doctrine that acquired traits and qualities
are not inheritable he seems to draw a hard and fast line separating
the mortal from the immortal parts or organisms. He also devoted the
greatest ingenuity in evolving an intricate scheme of biophores,
ids, idants, determinants, etc., inherent in germ cells, in order to
explain the phenomena of heredity. His studies have had great influence
in directing the attention of investigators to the most elementary
structures and functions of germ plasm and the remarkable changes
within cells that occur in the very earliest stages of embryonic
development; while, as we shall see, many of the most recent researches
have been directed, since his work was done, to the conditions under
which somatic cells in different tissues of the animal body can be made
to proliferate and grow, under carefully controlled conditions, more
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