Case 3. This was a wholesale merchant of 66 who for some five years had shown senile symptoms, such as difficulty of respiration and in thinking, weak memory and also muscles, and libido almost gone. In this case there was rapid prostatism and catheterization, also emaciation, and occasionally more pronounced psychic disturbances. The first operation on this case was prostatomy but this did not arrest loss of weight or increasing weakness. Then there was ligature of the vas near its entrance into the epididymis on both sides, which was followed by a very rapid recovery, with improvement of nearly all symptoms. Thus the author thinks that in fighting old age orthoplasty is by far the best method, and to the objection that these cases are not true psychic senescence but only symptoms of intercurrent disease he replies that this only gave occasion for the operation and that the disease itself was the result of age. Thus, in general, he concludes that for advanced senescence the ligature of the vas, as above, gives the most remarkable results, and that for those before the senium also it may often work very favorably. The same is true of premature old age, the advent of which has immense individual variations. As to checking the advance of old age in women, Steinach is not yet ready to make any positive report, but in view of what has already been done with animals he thinks a good prognosis can be made and that the best method is by implantation of young ovarian material. The difficulty of this orthoplastic process is found only in the dependence upon the material of implantation, which is very difficult to secure. The effort is directed in all such cases to the influence of the aging ovaries, whether operative by orthoplastic transplantation or by the use of Roentgen rays. The former, on account of the earlier involution of ovaries, is confined within certain limits to women. The phenomena of fatigue, etc., have been removed by this method, which has been so successful that improvement has been noticed by friends.