improvement took place. The ape is, in a sense, however, superior to man, as represented by the quality of these organs, owing perhaps to a more robust physical constitution; or it may be due to the fact that with the first boy the graft was from a young ape and the latter from his mature mother. For woman, for whom old age has perhaps even greater terrors than for man, such restoration has not yet been made. Indeed, ovariotomy has less effects upon young women than does castration upon man, so that here we face a new problem that cannot yet be solved. The problem now is whether we can generalize yet from these special studies, including bone grafting and the surgery of transplantation of other organs. Kidney grafting has been successful as yet only on cats and dogs but opotherapy or the administration of glandular extracts of animals when our own fail is in its infancy, although it does seem to give promise of deferring death and increasing the vigor of human life. Indeed, he thinks that the renewal of worn-out glandular mechanisms by grafting may even become a commonplace. The vital fluid supplied by these organs “restores energy in all cells and spreads happiness and a feeling of well-being and the plenitude of life throughout our organism.” The idea of controlling this marvelous force and placing it at our service when the natural sources of our energy begin to dry up with the advance of age has long haunted the minds of investigators, and Paul Bert and Ollier decades ago dreamed of a day when old organs might be set aside like worn-out clothes and replaced by new ones. “Several of these animals operated upon have exceeded the age limit which animals of their species generally attain and, instead of showing signs of decrepitude and senility, they give promise of astonishing vigor.” Louis Berman, M.D.,[191] tells us that infancy is the epoch of the thymus, childhood of the pineal, adolescence of whatever gland is left in control as the result of the life struggle, and senility is the epoch of gradual endocrine insufficiency. The discovery of the effects of endocrine secretions he compares with that of radium and thinks that by control of this function we may be able to modify the rigidity of Weismann’s dogma and affect heredity itself. He draws a very long bow and even attempts to characterize important personages and races according to the predominance of thyroid, pituitary, or adrenal secretions and sees here the fundamental determinants of human character and conduct. Well informed and expert as he is in this field, his views, though bold and interesting, are, it must be admitted, more or less speculative in the present state of our knowledge, and he devotes little consideration to old age or to the methods of deferring it.