The microscopic examination showed a generalized early chromatolysis in the nerve cells of varying intensity, especially affecting the small cells. The Nissl granules of the larger cells were also somewhat abnormal, being smaller and packed rather loosely together. The small cells of the bulb and pons were slightly swollen and their nuclei large and clear. As to the larger cells of the bulb and pons, there was less evidence of this swelling and nuclear change. According to Mott, this chromatolysis may perhaps be regarded as a sign of loss of biochemical neuropotential. The chromatolysis indicates a relative degree of exhaustion of the kinetoplasm. Mott assumes that the cells of this victim of shell-shock are in a state of beginning nervous exhaustion. He remarks that the cells of the vago-accessorius nucleus show more signs of this nervous exhaustion than others. With respect to cerebellar findings Mott remarks that the changes found are very similar to those described by Crile in the case of an exhausted and wounded soldier. Mott correlates the mania shown on the evening of February 23 with the venous congestion of the cortex, the small subpial hemorrhages and evidence of scattered arterio-capillary collapse. HISTOPATHOLOGY OF CASE OF SHELL-SHOCK, BURIAL, GAS POISONING? (F. W. MOTT) [Illustration: Punctate hæmorrhages in corpus callosum from a case of shell-shock and burial; very probably accompanied by gas poisoning while lying unconscious and buried. Observe the small white area in the centre of the hæmorrhage, in the middle of which is a small vessel which, under a higher magnification, will be seen to contain a hyaline thrombus. (× 20.)] [Illustration: Hyaline thrombus of vessel in centre of a punctate hæmorrhage. The thrombus was stained brown by dissolved pigment. Around the blocked vessel is a white area of brown substance containing numbers of leucocytes; outside this is the hæmorrhage, not very distinctly seen. The specimen was prepared from the subcortical white matter of the frontal lobe. (× 345.)] [Illustration: Leash of small perforating optostriate arteries filled with pigment granules. Two of the arterioles show miliary aneurisms. (× 350.)] [Illustration: Three punctate hæmorrhages showing optostriate arterioles filled with pigment granules. (× 30.)] HISTOPATHOLOGY OF SHELL-SHOCK (F. W. MOTT) NOTE THAT THE CHANGES IN CELLS OF FIG. 3 ARE DIFFERENTIAL FOR NUCLEUS AMBIGUUS: CELLS NEARBY PROVED NORMAL [Illustration: FIG. 1.--Photomicrograph of section of corpus callosum from case of shell-shock showing the capillary punctate hæmorrhages. In several a small white area is seen of brain tissue in the centre of which is a small artery or vein. (Magnification 20 diameters.)]