Mrs. Holder went on in her tranquil course, ministering to the poor around her. In early days she had made a careful study of such medical science as was then known. Barbarous as the surgery was, the remedial part of medicine appears to have been somewhat better understood. The circulation of the blood had very lately been discovered by Harvey; and whether it was the efficacy of the herbs and simples used, or the faith of the patients, or both, it is certain that many cures were made and much suffering alleviated. It is said of Mrs. Holder that 'she happily healed thousands.' She cured Charles II. of a hurt in his hand, whether in his early days of peril and wandering, or in later life, is not said. After the Restoration she was connected more or less with the Court, as her husband was subdean of the Chapels Royal, and she healed Queen Catharine and many of the Court. When one reads in Evelyn's or in Pepys' diary of the frightful remedies used: the 'hot fire pans' applied to the head in cases of apoplexy, the constant bleeding, the roughness of the entire treatment, one is thankful to think that they were occasionally ministered to by the gentler hand of a woman. A taste for the science of medicine seems to have been common in the Wren family. Sir Christopher studied it at Oxford under Sir Charles Scarborough and drew the plates for Dr. Thomas Willis' 'Cerebri Anatome,' which was in great repute. His cousin, Thomas Wren, made it a matter of serious study, probably living by it as a profession at the time when Bishop Wren's imprisonment left his younger children penniless. The same honourable calling was chosen by Sir Christopher's grandson, Stephen Wren. Among all the patients whom good Mrs. Holder tended and cared for, in none could she have taken more pride than in the brother over whose sickly childhood she had watched, and whose fame she saw daily increasing. Nor was there any drawback to her delight: loving, gentle, modest, and courteous he had been as a boy, and the famous successful architect possessed those qualities still. In a corrupt age, all testimony leaves him spotless; in positions of great trust and still greater difficulty his integrity was but the more clearly shown by the attacks made against him; among the foremost philosophers of his age, he was a striking example that 'every good gift and every perfect gift is from above;' no child could hold the truths of Christianity with a more undoubting faith than did Sir Christopher Wren. ['_I THINK THEY ARE HIGH ENOUGH._']