As undeveloped as the pueblo was, Los Angeles boasted, in her very infancy, a number of physicians, although there were few, if any, Spanish or Mexican practitioners. In 1850, Drs. William B. Osburn, W. W. Jones, A. W. Hope, A. P. Hodges and a Dr. Overstreet were here; while in 1851, Drs. Thomas Foster, John Brinckerhoff and James P. McFarland followed, to be reënforced, in 1852, by Dr. James B. Winston and, soon after, by Drs. R. T. Hayes, T. J. White and A. B. Hayward. Dr. John Strother Griffin (General Albert Sidney Johnston's brother-in-law and the accepted suitor of Miss Louisa Hayes) came to Los Angeles in 1848, or rather to San Gabriel--where, according to Hugo Reid, no physician had settled, though the population took drugs by the barrel; being the ranking surgeon under Kearney and Stockton when, on January 8th, they drove back the Mexican forces. He was also one of the hosts to young W. T. Sherman. Not until 1854, however, after Griffin had returned to Washington and had resigned his commission, did he actually settle in Los Angeles. Thereafter, his participation in local affairs was such that, very properly, one of our avenues is named after him. Dr. Richard S. Den antedated all of these gentlemen, having resided and practiced medicine in Los Angeles in 1843, 1844 and again in the early fifties, though he did not dwell in this city permanently until January, 1866. Den I knew fairly well, and Griffin was my esteemed physician and friend. Foster and Griffin were practitioners whom I best recall as being here during my first years, one or two others, as Dr. Osburn and Dr. Winston, having already begun to devote their time to other enterprises. Dr. Richard S. Den, an Irishman of culture and refinement, having been for awhile with his brother, Nicholas Den, in Santa Bárbara, returned to Los Angeles in 1851. I say, "returned," because Den had looked in on the little pueblo before I had even heard its name. While in the former place, in the winter of 1843-44, Den received a call from Los Angeles to perform one or two surgical operations, and here he practiced until drawn to the mines by the gold excitement. He served, in 1846-47, as Chief Physician and Surgeon of the Mexican forces during the Mexican War, and treated, among others, the famous American Consul Larkin, whose surety he became when Larkin was removed to better quarters in the home of Louis Vignes. Den had only indifferent luck as a miner, but was soon in such demand to relieve the sufferers from malaria that it is said he received as much as a thousand dollars in a day for his practice. In 1854, he returned to Santa Bárbara County, remaining there for several years and suffering great loss, on account of the drought and its effects on his cattle. Nicholas Den, who was also known in Los Angeles, and was esteemed for both his integrity and his hospitality, died at Santa Bárbara in 1862.