In the autumn following his graduation, in 1833, young Spalding went to Lexington, Ky., hoping to obtain employment as a teacher. The effort to establish a private classical school in Lexington, though widely advertised, was not successful. The patronage did not answer to the promises of the ambitious prospectus, and, after a trial of a few weeks, the enterprise was abandoned as unremunerative. The West was not to be the scene of Dr. Spalding's life, nor teaching his employment. Mr. Spalding returned to New England in the spring of 1834, and commenced the study of medicine in the office of his father at Amherst. He attended three courses of lectures in the Harvard Medical School at Boston, and was graduated at that institution in the summer of 1837. Having spent a few months riding with his father, and observing his treatment of the sick, he decided to enter on what seemed a promising field for a physician at Nashua. Accepting an invitation from the elder Dr. Eldredge, he became a partner with him in practice. After this partnership was dissolved the business increased, and he gained for himself an extensive and valuable patronage. He enjoyed the confidence of a large circle of families, and his success as a physician had given him an enviable reputation. In the meantime he had been called to assume responsibilities of a fiduciary nature, involving such care and labor as seriously to interfere with his professional engagements. The transition to these new employments was the natural sequence of the excellent judgment and rare capacity for business which he manifested. The accuracy and promptitude with which his accounts were rendered to the probate, and the just consideration for the feelings and interests of all persons concerned in the settlement of the estates committed to his trust, brought such a pressure of occupation that he was compelled to relinquish his profession. He had now been in practice twenty-five years, and satisfactory as his services as a physician had been to the community, he was yet to perform an imperative and valuable service by his judicious management of important trusts and his earnest co-operation in the direction and enlargement of new enterprises. In addition to his engagements in the settlement of large estates, he became interested in banking, manufacturing, and railroads, holding various offices of labor and responsibility in these institutions and corporations. He was for several years treasurer of the Nashua Savings Bank and subsequently its president. He was one of the original projectors of the "Pennichuck Water-Works," of which company he is president. A director in both of the large cotton manufacturing companies which have contributed so much to the prosperity of the city, he has also fulfilled similar duties in other corporations elsewhere. For a time a director, he has become the president, of the Indian Head National Bank.