Herpes zoster, though far from confined to advanced life, has in the old the unfortunate tendency to leave persistent pain in its site. Rodent ulcer, although sometimes seen comparatively early in life, is specially common in advanced years. It often supervenes on the dry yellow or brown spots (senile keratosis) seen on the face in persons over 60 years of age. _Vertigo_ is extremely common in later life and may be due to various causes; the most frequent form is that of aural origin, such as labyrinthine or nerve lesions and chronic changes in the middle ear. Increased blood pressure and cerebral arteriosclerosis are frequently responsible. Attacks of giddiness may occur in Stokes-Adams disease or follow exertion in the aged, as if from cerebral anaemia; and gastric disturbance may apparently also be a determining factor. In rare instances epilepsy or migraine may be represented or initiated by vertigo. _Senile tremor_, rare under the age of 70, begins in the hands, especially in that most used, and spreads to the neck and head, rarely occurring in the lower limbs. It is a slow intention tremor, from 4 to 5 per second, and is distinguished by its relation to movement from that of paralysis agitans which is continuous but diminished on muscular contraction. The tremor of the jaw resembles that of munching food; that of the lips is fine. It is compatible with good health. _Paralysis agitans_, described by James Parkinson, surgeon and palaeontologist, in 1817 as “the Shaking Palsy,” has now about a century later been shown, largely as a result of S. A. K. Wilson’s work, to be one of the forms of the extra-pyramidal symptom complex and due to degenerative changes in the efferent motor system of the globus pallidus system. Although juvenile forms occur and encephalitis lethargica may show the Parkinsonian syndrome, paralysis agitans is a disease of the early part of the later period of life, the great majority of the cases beginning between 50 and 70 (Gowers[205]), after which there is a small incidence only. It is twice as common in males as in females. Though unfortunately, from the degenerative nature of the lesion, incurable, it is a chronic disease; thus Maclachlan[206] refers to a Chelsea pensioner aged 107 years in whom it was known to have existed for 47 years.