_Osteitis deformans_ or Paget’s disease of bone begins as a rule in the later half of life, the average age being 50 years. Lannelonge[227] and Fournier[228] argued that it is a lesion due to congenital syphilis; but although luetic periostitis and osteitis may imitate it, there is no convincing evidence in favour of their contention. FOOTNOTES [1] _Thomas Linacre_, Linacre Lecture, 1908, St. John’s College, Cambridge, by William Osler, M.D., F.R.S., Cambridge University Press, 1908. [2] _Life of Thomas Linacre_, by John Noble Johnson, M.D., p. 344, 1835. [3] _De Temperamentis_, _Galeni Pergamensis_, etc. (translated by Thomas Linacre), by J. F. Payne, p. 5, Cambridge, 1881. [4] The fourth of the five epidemics of the remarkable disease the English Sweating Sickness between 1486 and 1551 occurred in 1528–1529, and is regarded by Dr. F. G. Crookshank as influenza [_Proc. Roy. Soc. Med._, 1922, xv. (Sect. Hist. Med.) 27]. [5] The portrait of Heberden in his 86th year was painted by Sir William Beechey, R.A., who when he got to Windsor found he had forgotten his canvas and sent for a shirt on which he painted the picture, now in the dining-room of the Master’s Lodge, St. John’s College, Cambridge; there are two copies in the possession of the Heberden family, and one in the Censors’ room of the Royal College of Physicians. For some of this information I am indebted to Mr. W. B. Heberden and to Mr. W. Fleming, Bedell of the Royal College of Physicians of London. [6] The Cambridge University Press, 1913. [7] _Vide Gentleman’s Magazine_, 1851, N.S., xxxv. part i. 205. [8] Γηροκομία βασιλική or _The Pourtract of Old Age wherein is contained a Sacred Anatomy, both of Soul and Body, and a Perfect Account of the Infirmities of Age Incident to them Both_, by John Smith, M.D., London, 1665. [9] Maupas, _Arch. de zool. expér._, 1899. [10] Woodruff, L. L., _Proc. Nat. Acad. Sc._, Washington, D.C., 1921, vii. 43. [11] Woodruff and Erdmann, _Proc. Soc. Exper. Zool._, N.Y., 1913–14, xi. 73. [12] Child, C. M., _Senescence and Rejuvenescence_, p. 310, Chicago, 1915. [13] Huxley, J. S., _Journ. Microscop. Sc._, 1921, lxv. 643. [14] Robertson, T. B., and Ray, L. A., _Journ. Chem. Biol._, 1919, xxxvii. 455. [15] Drummond and Cannan, _Biochem. Journ._, Cambridge, 1922, xvi. 53. [16] Sisson and Broyles, _Johns Hopkins Hosp. Bull._, Baltimore, 1921, xxxii. 22. [17] Hopkins, G., _Journ. Physiol._, Cambridge, 1912, xliv. 425. [18] Osborne, T. B., and Mendel, L. B., _Journ. Biol. Chem._, 1915, xxiii. 439. [19] Metchnikoff, _The Nature of Man_, English translation, 1903, p. 272. [20] Browne, T., _Pseudodoxia Epidemica_, p. 396, 6th edition, 1672. [21] Eugenius Philalethes, junior, F.R.S., _Long Livers: A curious History of such Persons of both sexes who have liv’d several Ages, and Grown Young again_, 1722, p. 27. [22] Hufeland, C. W., _The Art of Prolonging Life_, vol. i. p. 121, English translation, 1797.