Life cycle, experimental modification of, 11 Ligament, spinous, ossification of, 99 Ligamentum spirale, atrophy of, 118 Linacre, Thomas, 2 family history of, 2, 3 Linacre Lectures, 3–6 Linacre Lectureship, 1 Lips, tremor of, 144 Lipschülz, 74 Liveing, G. D., 7 Liver, atrophy of lobules and cells of, 102 changes in size and weight of, 102 cirrhosis of, 140 Llewellyn, L. J., 154 Longevity, alcohol influencing, 57 among professional men, 50, 53 auto- and hetero-suggestion influencing, 48, 49 “cell-memory” in relation to, 35 climatic conditions influencing, 39, 41 conditions favouring, 7, 33 diseases inimical to, 45 endocrine atrophy in relation to, 68–81 environment influencing, 33, 34, 39–46, 55 factors influencing, 32 fertility in relation to, 23, 24 functional activity influencing, 46, 55 hereditary aspects of, 19, 32–39 idleness inimical to, 47, 48 in the medical profession, 52 influence of past diseases on, 43 influence of blood pressure on, 37 influence of brain cells on, 36 integrity of cardio-vascular system necessary to, 36 of nations, compared, 39, 40 of the patriarchs, 15, 16 personal habits influencing, 55 potential, on what determined, 67 sex incidence of, 21, 22 smoking in relation to, 58 syphilis preventing, 45 vitality of central nervous system essential to, 36 _See also_ Old Age; Senescence Lorand, A., 70 Lowe, Peter, 131 Luciani, 18, 102 Lungs, changes in, 103 diseases of, 147, 148 Lydston, G. F., 71 Lymphadenoma, 141 Lymphoid tissues, atrophy of, 63, 108 Maclachlan, D., 144 Maignon, Abbé, centenarian, 50 Malignant disease, 87, 141 cell senility in relation to, 88 Mammae, involution changes in, 114 Mania, senile, 145, 146 Mansell-Moullin, C. W., 78 Mansfield, Lord, octogenarian, 51 Marasmus, senile, 139 Marie, P., 146 Marinesco, 64, 78, 83, 97 Marx, K., 47 Mead, Richard, 131 Medical men, centenarians among, 52 duration of life of, 52, 53 Melancholia, senile, 146 Memory, impairment and loss of, 120, 122 Menopause, onset of old age at the, 26 ovarian changes at, 63, 79 Mental activity, influence on old age, 47, 48, 50, 54 unimpaired, in advanced age, examples of, 50, 51, 53 Mental deterioration, 49, 119, 122, 145, 146 causes of, 47, 48, 49 onset of, 53 Mental fatigue, tendency to, 120 Mental state, 119, 122, 123 and the physical, want of harmony between, 123 influence of, 48–50 Metabolism, disordered, 115, 116, 117, 154 gland therapy stimulating, 72, 81 Metchnikoff, E., 8, 13, 18, 82–86, 91, 97, 123 Methuselah, 14 Michael Angelo, mental activity at advanced age, 53 Micturition, disorders of, 153 Middle ear lesions, 143 Migraine, 140 Miles, W. E., 153