Shaking palsy, 144 Sharpey-Schafer, E. A., 63 Sight, impairment of, 117 Sinclair, John, 8, 20, 35 Singer, C., 86 Skeleton, changes in, 98 Skin, 93, 115 diseases of, 141 disposition to, 141 dry, 115 venules and angiomas on, 108 Skull, 100 Sleep, diminished, 119 over-indulgence in, 60 Smell, impairment of sense of, 117 Smith, John, 8, 131 Smith, Lapthorn, 53 Smoking, influence on longevity, 58–59 Sophocles, mental activity at advanced age, 53 Sour milk, destruction of intestinal bacteria by, 83 Spasm of arteriosclerotic vessels, 151 Spastic paraplegia, 147 Spinal cord, degenerative changes in, 97, 147 Spleen, atrophy of, 63, 109 Spondylitis, rhizomelic, 155 Spondylitis deformans, 99, 155 Stapes, fixation of, 118 Starvation, influencing the onset of senescence, 56, 57 Starvation treatment, 56, 57 Steinach, E., 11, 77, 78 Sterne, John, on the attainment of old age, 16 Stevenson, T. H. C., 41 Strachey, L., 47 Structural changes of the body, 90 Symmers, D., 102 Syphilis, influence on longevity, 45 Taste, impairment of, 117 Teeth, decay of, 44, 101 loss of, 44, 45, 99, 101 causes of, 101 Temperance, a characteristic of centenarians, 57 Temperature, and longevity, 26 of body, 116 Testes, atrophy of, 113 cells of, activity and function of, 73, 74 in relation to senescence, 75 changes in, following vasectomy, 77, 78 internal secretion of, 69–72, 74 prostatic atrophy in relation to, 112 Testicular extract, rejuvenescence in relation to, 80 Testicular grafts, rejuvenation by, 71, 72, 77 results of experiments, 76, 79 Thompson, R. J. C., 37, 44, 49, 96, 125 Thompson, W. J., 40 Thrombosis, 144 age incidence of, 145 cerebral, 145 venous, 151 Thymus, atrophy of, 109 Thyroid deficiency, 138 baldness resulting from, 96 effect on activity of body cells, 72 prostatic enlargement in relation to, 113 Thyroid extract, rejuvenescence in relation to, 80 for prostatic enlargement, 113 Thyroid gland, degenerative changes in, 109, 110 Tinnitus, 118 Tissues, connective, relation of cellular activity to, 68, 88, 89, 92 Titian, 53 Tobacco, and arteriosclerosis, 59 influence on longevity, 58 symptoms due to, 59 Todd, R. E., 37, 44, 49, 125 Toxaemia, as a cause of senescence, 82, 86 degenerative changes due to, 44, 55, 56, 86 intestinal, as cause of senescence, 82, 85 over-eating causing, 56 Transfusion, 66 Tremor, senile, 143 Tropical life, influence on longevity, 26, 36, 39 Trousseau, 151 Tuberculosis, senile, 148 Tumours, 86, 141 Turnbull, H. M., 106, 114 Ulcer, rodent, 143 Urea-nitrogen in the blood, 115 Urinary bladder, hypertrophy of, 153 Urine, condition of, 126 Uterine changes, 114 Valvulitis, chronic, 149, 150 Vanity, senile, 120, 121 Variation, correlated, 23