The disease does not always appear in its full severity; for a day, or even two, however, there may be merely loss of appetite, impaired rumination, a disposition to remain lying down, yet when the patient is raised it manifests suffering by anxiously looking at the flanks, shifting or stamping of the hind feet, shaking of the tail, and attempts to urinate, which are either fruitless or lead to the discharge of a small quantity of high-colored or perhaps bloody urine. In some recent slight cases, and in many chronic ones, these symptoms may be absent or unobserved, and an examination of the urine is necessary to reach a safe conclusion. The urine may contain blood, or it may be cloudy from contained albumin, which coagulates on heating with nitric acid (see "Albuminuria," p. 121); it may be slightly glairy from pus, or gritty particles may be detected in it. In seeking for casts of the uriniferous tubes, a drop may be taken with a fine tube from the bottom of the liquid after standing, and examined under a power magnifying 50 diameters. If the fine, cylindroid filaments are seen they may then be examined with a power of 200 or 250 diameters. (Pl. XI, fig. 5.) The appearance of the casts gives some clue to the condition of the kidneys. If made up of large, rounded or slightly columnar cells, with a single nucleus in each cell (epithelial), they imply comparatively slight and recent disease of the kidney tubes, the detachment of the epithelium being like what is seen in any inflamed mucous surface. If made up largely of the small, disk-shaped and nonnucleated red blood globules, they imply escape of blood, and usually a recent injury or congestion of the kidney--it may be from sprains, blows, or the ingestion of acrid or diuretic poisons. If the casts are made of a clear, waxy, homogeneous substance (hyaline), without any admixture of opaque particles, they imply an inflammation of longer standing, in which the inflamed kidney tubules have been already stripped of their cellular (epithelial) lining. If the casts are rendered opaque by the presence of minute, spherical granular cells, like white blood globules, it betokens active suppuration of the kidney tubes. In other cases the casts are rendered opaque by entangled earthy granules (carbonate of lime), or crystals of some other urinary salts. In still other cases the casts entangle clear, refrangent globules of oil or fat, which may imply fatty degeneration of the kidneys or injury to the spinal cord. The presence of free pus giving a glairy, flocculent appearance to the urine is suggestive of inflammation of the urinary pouch at the commencement of the excretory duct (pelvis of kidney) (Pl. IX, fig. 1), especially if complicated with gritty particles of earthy salts. This condition is known as pyelitis. In the chronic cases swelling of the legs or along the lower surface of chest or abdomen, or within these respective cavities, is a common symptom.