Fatty degeneration and calcification of the middle and outer coats may occur, and large, hard, calcareous plates project inward, upon which thrombi may form or may exist in connection with atheroma of the inner coat. When there is much thickening and increase of new tissue in the wall of the affected artery it may encroach upon the capacity of the vessel, and even lead to obliteration. This is often associated with interstitial inflammation of glandular organs. _Treatment._--Carbonate of potassium in 1-dram doses, to be given in 4 ounces liquor acetate of ammonia every six hours; scalded bran sufficient to produce loosening of the bowels, and complete rest; externally, applications of hot water or hot hop infusion. ATHEROMA. Atheroma is a direct result of an existing chronic endarteritis, the lining membrane of the vessels being invariably involved to a greater or less degree. It is most frequently found in the arteries, although the veins may develop an atheromatous condition when exposed to any source of prolonged irritation. Atheroma may affect arteries in any part of the body; in some instances almost every vessel is diseased, in others only a few, or even parts of one vessel. It is a very common result of endocarditis extending into the aorta, which we find perhaps the most frequent seat of atheroma. As a result of this condition the affected vessel becomes impaired in its contractile power, loses its natural strength, and, in consequence of its inability to sustain its accustomed internal pressure, undergoes in many cases dilatation at the seat of disease, constituting aneurism. In an atheromatous vessel, calcareous deposits soon occur, which render it rigid, brittle, and subject to ulceration or rupture. In such vessels the contractility is destroyed, the middle coat atrophied and beyond repair. Atheroma in the vessels of the brain is a frequent cause of cerebral apoplexy. No symptoms are manifested by which we can recognize this condition during life. CONSTRICTION OF AN ARTERY. This is usually the result of arteritis, and may partly or wholly be impervious to the flow of blood. When this occurs in a large vessel it may be followed by gangrene of the parts; usually, however, collateral circulation will be established to nourish the parts previously supplied by the obliterated vessel. In a few instances constriction of the aorta has produced death. ANEURISM. Aneurism is usually described as true or false. True aneurism is a dilatation of the coats of an artery over a larger or smaller part of its course. Such dilatations are usually due to chronic endarteritis and atheroma. False aneurism is formed after a puncture of an artery by a dilatation of the adhesive lymph by which the puncture was united.