By thrombosis is generally understood the partial or complete closure of a vessel by a morbid product developed at the site of the obstruction. The coagulum, which is usually fibrinous, is known as a thrombus. The term "embolism" designates an obstruction caused by any body detached and transported from the interior of the heart or of some vessel. Thrombi occur as the result of an injury to the wall of the vessel or may follow its compression or dilatation; they may result from some alteration of the wall of the vessel by disease or by the retardation of the circulation. These formations may occur during life, in the heart, arteries, veins, or in the portal system. When a portion of fibrin coagulates in one of the arteries and is carried along by the circulation, it will be arrested, of course, in the capillaries, if not before; when in the veins, it may not be stopped until it reaches the lungs; and when in the portal system the capillaries of the liver will prevent its further progress. The formation of thrombi may act primarily by causing partial or complete obstruction, and, secondarily, either by larger or smaller fragments becoming detached from their end and by being carried along by the circulation of the blood to remote vessels, embolism; or by the coagulum becoming softened and converted into pus, constituting suppurative phlebitis. These substances occur most frequently in those affections characterized by great exhaustion or debility, such as pneumonia, purpura hemorrhagica, endocarditis, phlebitis, puerperal fever, hemorrhages, etc. These concretions may form suddenly and produce instantaneous death by retarding the blood current, or they may arise gradually, in which case the thrombi may be organized and attached to the walls of the heart, or they may soften, and fragments of them (emboli) may be carried away. The small, wartlike excrescences occurring sometimes in endocarditis may occasionally form a foundation on which a thrombi may develop. _Symptoms._--When heart clot, or thrombus, exists in the right side, the return of blood from the body and the aeration in the lungs is impeded, and if death occurs, it is owing to syncope rather than to strangulation in pulmonary respiration. There will be hurried and gasping breathing, paleness and coldness of the surface of the body, a feeble and intermittent or fluttering pulse, and fainting. When a fibrinous coagulum is carried into the pulmonary artery from the right side of the heart, the indications are a swelling and infiltration of the lungs and pulmonary apoplexy. When the clot is situated in the left cavities of the heart or in the aorta, death, if it occurs, takes place either suddenly or at the end of a few hours from coma.