Studies on Epidemic Influenza: Comprising Clinical and Laboratory InvestigationsUniversity of Pittsburgh. School of Medicine
History
Studies on Epidemic Influenza: Comprising Clinical and Laboratory Investigations
University of Pittsburgh. School of Medicine
Influenza; Influenza Epidemic, 1918-1919
The findings of the bacteria in the lung sections are particularly
interesting and instructive. The entire series of cases have not been
completely studied, so I am unable to tabulate the findings. In cases
761 and 762 sections of the lung showed influenza-like bacilli to be
almost pure in the earlier stages of the process, while in areas with
purulent foci pneumococcus-like and other Gram positive cocci were also
numerous. In some cases B. influenzæ-like organisms were to be seen in
overwhelming numbers. In others they were scarce, while in some nothing
resembling B. influenzæ could be found in the sections. Positive
cultures were often independent of whether the influenza-like forms were
to be seen in smears or sections or not, although they were found in the
great majority of the cases. The findings in the direct smears and the
bacteriological results make useful material for comparison.
Swabs from the nasopharynx were cultured from 31 individuals; nearly all
of these were cases suspected of diphtheria or as carrying the
diphtheria bacillus, and no particular effort was made to isolate the B.
influenzæ. They were seen in the mixed culture occasionally. In the last
eight cases the heated blood agar, ordinary blood agar and Loeffler’s
serum were seeded from the throat swabs. B. influenzæ practically
overgrew all the other bacteria from seven of these cases on the heated
blood agar medium and was isolated without difficulty; all eight showed
M. catarrhalis. The two other media gave little or no evidence of the
presence of B. influenzæ. As I have said above, our attention was
concentrated on the autopsy material. These cultures from the throat
were simply made to demonstrate the usefulness of the heated blood agar.
TABLE II
BACTERIA SEEN IN DIRECT SMEARS FROM NASOPHARYNX
════════════╤═════════╤═══════════════╤══════════════════╤═════════════════
Type of │Number of│ B. │ │ M.
Disease. │Patients.│Influenzæ-Like.│Pneumococcus-Like.│Catarrhalis-Like.
────────────┼─────────┼───────────────┼──────────────────┼─────────────────
Early │ 24│ 14│ 17│ 6
Serious │ 13│ 13│ 13│ 9
Convalescent│ 11│ 8│ 11│ 6
────────────┼─────────┼───────────────┼──────────────────┼─────────────────
Total │ 48│ 35│ 41│ 21
Percentage │ │ │ │
of │ │ │ │
positives │ │ 73│ 86│ 43
────────────┴─────────┴───────────────┴──────────────────┴─────────────────
_Direct Smears from Nasopharyngeal Swabs_
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