Studies on Epidemic Influenza: Comprising Clinical and Laboratory InvestigationsUniversity of Pittsburgh. School of Medicine
History
Studies on Epidemic Influenza: Comprising Clinical and Laboratory Investigations
University of Pittsburgh. School of Medicine
Influenza; Influenza Epidemic, 1918-1919
The hemophilic and hemolytic organisms described by Davis, which he
isolated from pathological urine, were non-symbiotic and non-pathogenic.
Koch has described a similar organism from puerperal infection. Whether
the hemophilic organism described by Thalhimer from the uterus in a case
of puerperal infection, those found by Cohen in urethral discharge in
one case and the pelvic exudate of another, and the findings of Kretz in
pyelitis, Wright in pyelonephrosis and Klieneberger in cystitis cases,
possibly refer to this same bacillus is, of course, uncertain. Pritchett
and Stillman found a somewhat similar bacillus, which they called
Bacillus X, from the mouths of 24 persons. It was hemophilic and
hemolytic, stouter than B. influenzæ and showed long tangled threads in
blood broth. It was non-pathogenic and is probably the same as Davis’
organism.
Davis described another hemophilic bacillus from a patient with purulent
foci which was non-hemolytic and non-symbiotic. It was grown from an
abscess of the shoulder joint, the blood and the bronchial secretion of
an infant. Cyanosis was a marked feature of this case. Paranhos
described a hemophilic bacillus from meningitis, which, however, was
Gram positive, and Moon reported an anærobic hemophilic bacillus from an
infection of the ethmoid sinus. The work of Jordan would suggest that
there may be two groups of B. influenzæ based on the indol production.
_Morphology._—The morphology of B. influenzæ has received more than
usual attention. In what we consider its characteristic form, it is an
extremely small bacillus, usually single but sometimes in pairs, and not
infrequently exhibiting polar staining. In direct smears, where there
are many bacteria present, they are frequently arranged in the schools
so frequently described. The development of thread forms is today
considered quite characteristic for B. influenzæ. The organisms vary
from moderately long bacillary forms to very long twisted or curled
threads suggesting leptothrix. In such cultures chains of tiny bacilli
are also quite often noted. At the other extreme we have exceedingly
tiny coccoid forms, resembling in size the B. bronchisepticus, which, as
Ferry has shown, are small enough to pass through many grades of
filters.
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