Studies on Epidemic Influenza: Comprising Clinical and Laboratory InvestigationsUniversity of Pittsburgh. School of Medicine
History
Studies on Epidemic Influenza: Comprising Clinical and Laboratory Investigations
University of Pittsburgh. School of Medicine
Influenza; Influenza Epidemic, 1918-1919
Other organs of the body are sometimes found to contain B. influenzæ.
Adrian, Schultes, Basile and Tedesko have all recovered this organism
from the diseased appendix. Several years ago a bacillus, considered, to
be B. influenzæ, was grown from the pus of an appendix abscess in our
laboratories. Wright found it in pyelonephrosis. Klieneberger found
influenza-like bacilli in cases of cystitis. Menko reported the bacillus
from orchitis, and Cohn found numerous influenza-like bacilli in the
discharge from urethritis. Meunier found it in pure culture in a case of
osteoperiostitis. Huyghe, Besancon and Griffon recovered it from
infected joints, as did Pacchioni in a general infection. Weil found it
in the pus about the hip joint one month after an attack of influenza.
This short review serves to illustrate that the influenza bacillus,
although generally limited to infections in the respiratory tract, is,
nevertheless, capable of infecting other parts.
_Immunity—Phagocytosis_
Phagocytosis of the B. influenzæ has been very frequently noted in the
study of sputum smears. It has been observed, moreover, that this
phenomenon occurs most frequently when the patient is on the road to
recovery (Pfeiffer, Martin, and others), and it may indicate an
important reaction on the part of the body to this organism. Tunnicliff
in a recent report, however, did not find the opsonic index to be raised
above the normal in her patients, and Tunnicliff and Davis had
difficulty with a spontaneous phagocytosis of this bacillus. This
difficulty was to a large extent absent in her later study.
_Agglutination_
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