+Nerve Pressure; Anemia.+ That motor and sensory paralysis followed pressure upon a nerve has been well known for many years, and this has been utilized in the effort to produce anesthesia, artifically by applying a rubber tube or bandage around a finger or extremity, with the hope that “ligation anesthesia” would follow the arrest of circulation. This, however, has been unsuccessful as all that was thus accomplished was a slight sensation of numbness with no arrest of the sense of pain. This method could only be successfully carried out, were the nerves themselves subjected to sufficient pressure to injure them. Return to normal sensibility and motor function could not be expected for months. +Cold.+ The addition of common salt to ice hastens its liquefaction and consequently renders the mixture more cold. This knowledge has been applied in a method of producing anesthesia of limited areas of the skin. A gauze bag of the correct shape and size is filled with salt and ice mixed, and applied to the area to be anesthetized. This method was used as far back as 1848, by Arnott, but was soon improved upon by Richet and others who used ether or rhigolene sprayed on the part to be anesthetized. It was found that extremely low temperatures could be obtained in this way, especially if a current of air were blown across the field of operation to hasten evaporation, and that a good local insensibility could be brought about if the circulation of warm blood could be either stopped or retarded with an Esmarch bandage or tourniquet. The method of obtaining local anesthesia through the agency of cold was found to be best accomplished by ethyl chloride and this substance is used in preference to any of the others previously mentioned, at the present time. Some years ago Dr. Martin W. Ware of New York experimented with both ethyl chloride and ethyl bromide and he found that the former was more serviceable in producing local anesthesia. +The Sensibility of Various Tissues.+ Karl G. Lennander, of Upsala, Sweden, shortly before his death, completed a chapter on local anesthesia for Keen’s “Surgery” in which is set forth an elaborate account of the sensibility to heat, cold, pressure, and pain of the various nerve terminals throughout the body. In this great work he has given the world the results of many experiments on living tissues, experiments investigating the degree and kind of the tissues sensibilities; thus it is learned that “all internal organs receiving their nerve supply only from the sympathethic nerve and from the vagus, below the branching-off of the recurrent nerve, have no sensation, and that the abdominal and pelvic viscera are devoid of nerves to convey the sense of pain, heat, cold, or pressure.” From the same authority we are taught that the parietal peritoneum is highly sensitive but that the visceral covering is devoid of all sensibility, enabling the operator much freedom of manipulation within the abdominal cavity.