+Endermic Method.+ This method is an end-organ anesthesia, and the solutions employed are strong and act because of their drug content. It is not in any sense a pressure anesthesia. The skin should be picked up and pinched hard for the better insertion of the needle directly into the skin substance. It is therefore endermic and the skin is seen to become blanched as the needle advances delivering its solution on the way. But little of the fluid is pressed out as the needle advances. When the syringe is empty or the needle has advanced to the limit of its length, refill and insert just inside of the last blanched spot and proceed in a line until the end of the contemplated line of incision is reached. Pressing out too much of the solution at one time causes a burning sensation and should therefore be avoided as the only pain should be that of the initial prick of the needle. Care, however, should be taken to inject just sufficient of the solution to penetrate beyond the zone of operation laterally, to insure sufficient space for the insertion of sutures into anesthetized tissues. Only a small quantity of fluid is necessary in this procedure as it comes in direct contact with nerve terminals. By touching the injected line with the needle in several places along its length and inquiring of the patient if it is felt, we may make sure of the completeness of the anesthesia before making the incision which should begin and end inside the anesthetized area. +Subdermic Method.+ An appreciable area of skin and subcutaneous tissue may be incised by anesthetizing as previously described, together with depositing the fluid well under the skin, thus affecting many terminal nerve branches before they reach their final distribution in the skin, and widening the anesthetized area considerably. This method is applicable to such work as the removal of small growths, and the deep incision of a carbuncle. Beneath the skin in the loose connective tissue the fluid is deposited and causes anesthesia by acting upon the nerves just before their emergence into the skin. The two methods may be combined. It is not possible to inject directly into thin skin or mucous membrane and it is therefore employed in such operations as circumcision, where the nerve terminals must be anesthetized by the diffusion of the anesthetic from its position under the skin. A little time should be allowed before beginning the operation to permit of the diffusion of the drug. This applies also to such operations as that for ingrown toe-nail where the deeper tissues down to the root of the matrix are involved.