Motion of the joints at this time is not painful, but the pain produced by percussing the bone, even lightly, may be intense. An extremely valuable diagnostic point is continued gentle pressure at some point over the shaft of the bone at a distance from the point of greatest constant pain. Usually, at a very early period, there appears swelling of the soft parts about the bone. This swelling, at first, is neither hot nor red, but soon becomes edematous, red, and shows pitting on pressure, and at that time may simulate acute phlegmon. In some cases the adjacent joint early becomes tender, hot and swollen, and this may occur even when there is no real extension of the infectious process to the joint itself. If extension does occur to the joint, swelling, tenderness, and pain on motion become more intense. The temperature usually is elevated to a considerable degree—103°F. or 104°F.—and usually the pulse is greatly accelerated. Evidence of constitutional disturbance and absorption of infectious material occur early. The tongue is dry, coated and tremulous; the face is drawn and flushed. Delirium of a mild type is a very common symptom, and in some cases this delirium may persist for a considerable length of time after the bone has been drained. Abscess of the soft parts may give deep or superficial fluctuation. Sinuses may appear. The leucocyte count is usually very high—25000 to 35000, and chiefly of a polynuclear type. Such a clinical picture is perfectly distinct, and it is difficult to overlook typical cases, especially after the fluctuation in the soft parts has occurred. The diagnosis of early cases, however, is sometimes very difficult, and even in the hands of experienced men, who have the lesion in mind, is frequently impossible. Even in severe cases, occasionally the pain itself is not severe for several days, when there may come a sudden exacerbation of symptoms. In the chronic stages of osteomyelitis the symptoms are usually characteristic. The limb is enlarged, the enlargement being partly due to thickening of the soft tissues, but chiefly to the formation of the involucrum. Usually running down to the sequestrum, are enormous sinuses, from which comes a foul, purulent discharge. On passing a probe, dead bone can be felt at the bottom of the sinuses. It must be borne in mind, however, that in a great many cases, after attacks of osteomyelitis of moderate severity, small localized abscesses are formed in the shaft of the long bones, with no sinus communicating with the surface. An abscess of this description, as has already been stated, is always surrounded by a wall of dense bonelike cortical bone.