As the impingement of the nerve is gradually relieved the disease is gradually modified and finally disappears. As the course of adjustments nears its conclusion and the impingement has been reduced to a comparatively slight one there may appear a stage of irritation of the nerve which is a reduplication of the first steps which appeared in the development of the disease. As most subluxations appear not all at once but by a series of changes, so disease develops synchronously, passing from stage to stage with the changes in the impingement. Often it passes through first an acute and active stage due to irritation and then a chronic and comparatively passive stage due to heavier, inhibiting impingement. Under adjustment these successive stages tend to reappear in reverse order, the most alarming sometimes appearing last and just before the cure is completed. It must be remembered that from the moment one practitioner administers medicine or other remedy and the other adjusts a vertebra, the clinical courses differ widely. No text-book on medical practice has as yet described the clinical course of the various diseases under Chiropractic adjustment. In chronic diseases where the nerves are paralyzed there may be a period under adjustment during which no change is apparent. This is followed by a period of rapid gain leading to complete recovery. This may be accounted for by the fact that the nerves are degenerated and must be repaired all along their course before communication is reestablished between nerve centers and peripheral organs. When this repair is sufficiently completed to allow communication, the cure is really well advanced, although evidence of it then first appears. This has been noted especially in locomotor ataxia. Cure of a Germ Disease First, under adjustment, the acute or acutely increased impingement is relieved. The caliber of the blood-vessels is at once regulated and the destructive action of fever checked. At the same time the vitality of the local tissue in which the germs are active is suddenly increased and there ensues a struggle between the body, as represented by its phagocytes and auto-protective chemicals, and the germs, which if adjustments be continued results in the rapid destruction of the germ colony. Also the elimination of the toxins already in the body proceeds so rapidly that if the fever can be held in check it takes only a short time for the body completely to overcome and eradicate the germs. Cure of Mental Disease