The frequency of adjustments in practice should be determined entirely by the nature of the case and the circumstances in which patient and adjuster are placed. No hard and fast rules can be laid down but some general advice may be profitable. Acute fever cases may be adjusted, until the fever is broken, oftener than any other type of cases. The chief object is the regulation of the temperature, after which the body is able properly to repair itself. Sometimes it may be necessary to give from two to six adjustments in a day and in at least one tetanus case the adjustments were given at intervals of about ten minutes for several hours until the fever was under control. After such a series it is wisest to refrain from adjusting again for several days so that the patient may recuperate during the interval, providing the fever does not return. It has been noticed that after a series of adjustments given at short intervals the improvement of the patient often extends over a period of days or weeks. In ordinary chronic cases, with good vitality and reactive power, the daily adjustment is best at first. Then after a course of from six to twenty-four adjustments according to the judgment of the practitioner, the interval is lengthened and adjustments given on alternate days, a day of rest intervening between each two. In weak patients or those who are extremely sensitive, the shock of the daily adjustment, even at first, and the demand on the body’s recuperative power may be greater than can be met. In this connection it may be mentioned that the author has encountered several cases of dorsal lordosis produced by too heavy and too frequent adjustments, straining the ligaments faster than they could be repaired and continuing the strain over too long a period. It is possible to _over-adjust_ a patient, producing a weakened spine and other deleterious effects, just as it is possible to establish a “tolerance” for a drug by long continued use. During a long course of adjustments it is well to allow the patient an occasional week of complete rest, or even more, and it may be wise after a time to reduce the number of adjustments to two per week in some cases. On the other hand, the practice of giving one adjustment a week from the beginning, as followed by some practitioners who maintain offices in numerous localities and visit each one day per week, is not generally productive of good results and it is the author’s practice to refuse new cases who profess their inability to take more than one adjustment weekly. The interval is so long that all repair work started by each adjustment is completed and an involutionary change sets in before the next. Specific vs. General Adjusting By specific adjusting is meant the selection and adjustment of the vertebra or vertebrae which are known to be causing definite disease or weakness. The term “specific adjustment” implies that there is a particular reason existing and recognized for every vertebra adjusted.