(_c_) The disturbance of the digestive organs is revealed by the dryness of the mouth and occasional excoriation of the tongue, which may be reddened or covered with white fur and silvery in appearance; salivation may be present instead of dryness of the mouth; there may also be irritation of the throat; symptoms of gastro-enteritis, _e.g._ nausea and vomiting, anorexia, diarrhœa, or alternating diarrhœa and constipation. (_d_) The skin eruptions are of various kinds, and comprise eczema, herpes, urticaria, erythema, keratosis, marked pigmentation and exfoliation. (_e_) The nervous symptoms are those of peripheral neuritis, numbness, formication, hyperæsthesia, and tenderness, especially of the soles of the feet, the latter presenting appearances of erythro-melalgia; there is some amount of paresis, in some cases amounting to absolute paralysis of the limbs affected. The hands may be anæsthetic, while the feet are hyperæsthetic and hyperalgesic, and the perspiration much increased. Mental symptoms are not common, but there may be hebetude, or delusions. In the Maybrick case, tried at the Liverpool Assizes in 1889, the following symptoms arose from repeated administration of arsenic during a period of probably about fourteen days. On April 27 Mr. Maybrick was seized with vomiting after taking tea. On the next day the vomiting continued, with foulness of the tongue, and he complained of stiffness in the lower limbs. On May 1 he complained of feeling unwell after taking luncheon, and he was sick on the following three days, and complained of a tickling sensation in the throat, with retching. On May 7 he was still suffering from vomiting, diarrhœa had commenced, and the throat was very dry and inflamed. On May 8 the diarrhœa was accompanied by tenesmus. On May 9 the tenesmus was distressing, and he died on May 11. Dr. Prosper de Pietra Santa describes a disease to which workers in manufactories of paper coloured with Schweinfurt-green are liable, characterised by the appearance of vesicles, pustules, _plaques muqueuses_, and ulcerations on the exposed parts of the body, fingers, toes, and scrotum. Arsenical poisoning has been mistaken for nettle-rash, scarlet fever, and Addison‘s disease. In cases of slow poisoning the symptoms resemble very much those of gastritis and ulcer of the stomach, and death due to the action of arsenic has been referred to “spontaneous inflammation of the bowels.” It must be remembered that in some cases of acute arsenical poisoning, when the acute symptoms have passed away, the nervous system exhibits its effects at a later period; in one case paresis came on on the fifth day, in another at the end of a week, and in a case recorded by Seeligmüller four weeks elapsed before the onset of nervous symptoms.