When _constitutional disturbance_ exists a rough or staring coat appears as one of the first symptoms, the sneezing is more violent, the nasal mucous membrane is more reddened and swollen, the eyes more dull, sunken and watery, the mouth hot and clammy, the temperature of the body raised, the pulse more frequent and having a sharper beat, the impulse of the heart may often be felt by applying the hand to the chest just behind the left elbow, the appetite is fastidious and the secretions of the bowels and kidneys are diminished, the latter being denser and more highly colored, from the absorption of irritating or infecting matters the glands under the throat are swollen and the swelling of the mucous membrane may be such as to impair breathing and even to threaten suffocation. In severe cases in which the inflammation extends to the nasal sinuses there is heat and tenderness over the forehead and the pain and weight are manifested by the pendent head and the red sunken, watery eyes and tumefied eyelids. When it extends to the throat, the cough, the difficulty in swallowing and the local tenderness on handling are characteristic. _Course._ With the occurrence of suppuration, improvement commences and if the inflammation does not extend beyond the nasal chambers, and if it is not kept up by a repetition or continuance of the cause the disease will have terminated in recovery in eight or ten days. For ulterior consequences in bad cases see _chronic catarrh_, _conjunctivitis_, _abscess of the nasal sinuses_, _laryngitis_, _stomatitis_, _staphylitis_.