Among _stimulants_, cubebs, cayenne pepper and copaiba have a stimulating and styptic effect on the mucous membrane and each of these has been successfully used in such cases. _Cantharides_, in five grain doses, have proved even more successful, (Vines, Percivall). _Sulphate of Copper_ in drachm doses in mucilage night and morning has proved very efficient (Sewell, Percivall). _Arsenious Acid_ has been employed with still better results. The dose, of five grains may be intimately mixed with a scruple of bicarbonate of soda and given daily in food.[1] Footnote 1: In giving this agent, any redness or watering of the eyes, or colicy pain should be carefully watched for, and when these premonitory symptoms of poisoning are noticed the medicine should be at once suspended to be commenced a few days later in smaller doses. But the most efficient tonic in these cases is arseniate of strychnia. Its good effects may be secured by combining with the above mentioned powders of arsenious acid and bicarbonate of soda, half a drachm of powdered nux vomica for each dose.[2] These powders will usually be taken in food, and may be continued for a month, or until the discharge ceases. Footnote 2: Whenever nux vomica or its alkaloids, strychnia or brucia, are given, increased irritability and nervousness should be carefully watched for and especially any involuntary twitching of the muscles. On their appearance the agent must be suspended and commenced a few days later in half the former doses. In all cases the general health must be carefully attended to. Keep the patient in a dry, clean, airy building without draughts of cold air; give moderate exercise in the open air; and good grooming; and allow nutritious food of mildly laxative properties,—as occasional bran mashes and roots in winter and succulent grasses in summer. _Local Applications._ These are the most important remedial measures and usually of themselves succeed in reestablishing a healthy condition. The agents proving most useful are of an astringent nature and in obstinate cases one may be substituted for another as the last appears to lose its effect. Sulphate of Zinc or Sulphate of Copper in the proportion of half a drachm of either to a quart of water, may be used, or if there is much fœtor, a solution containing a drachm each of carbolic acid and carbonate of potash in a quart of water is to be preferred. In either case the addition of an ounce of pure glycerine renders the lotion at once more soothing and more efficient. The solution must be rendered tepid before injecting it, to obviate the irritation attending on the contact of a cold fluid with the delicate membrane of the nose. Among other agents may be named creolin, creosol, creosote, acetate of lead, potassium permanganate, and silver nitrate. Peroxide of hydrogen may be used either as injection or in spray.