Frequently implicated in severe sore-throat the walls of the guttural pouches pour out pus as readily as other mucous membranes in a state of inflammation. As the escape of this product is hindered alike by the narrowness of the orifice and, in the elevated position of the head, by gravitation, it frequently becomes imprisoned and inspissated and proves a permanent source of irritation and discharge. In the early stages the contents are glairy with whitish or yellowish clots; later they are creamy, caseous or even cretaceous. The mucosa, at first red, congested and tumefied, becomes in chronic cases, hard, thick, puckered and adherent to adjacent structures. It sometimes ulcerates and the contents escape in mass, through the pharynx and nose, or externally behind the angle of the lower jaw. In the last case water swallowed may escape through the opening. More commonly the pus remains pent up, and thickens, and may dry and roll into round or oval pellets from the movements of deglutition. The discharge may be arrested for weeks or months when such masses block the outlet. _Symptoms._ The nasal discharge is intermittent or irregular, being often partially or wholly suppressed by keeping the head elevated, and reappearing or becoming profuse when it is lowered. Feeding from the ground, nibbling roots, or pasturing increases the discharge, as the dependent position of the outlet, the jerking and shaking of the head and the movements of deglutition all favor its exit. Swelling of the parotidean region, a flatness instead of resonance on percussion, and the flattening and discharge and sometimes gurgling by manipulation are characteristic. There is cough, roaring during active exertion, sometimes dyspnœa, and, in bad cases, food may be drawn into the bronchia with serious and even fatal results. When the orifice is blocked and the pouch filled with gas the elastic swelling and resilience are characteristic, and pressure may flatten it with a gurgling sound. These symptoms serve to differentiate it from peripharyngeal abscess. The submaxillary lymphatic glands are usually swollen but less than in glanders and not so hard. _Treatment._ In mild and recent cases in which the contents of the pouch have not yet become thick and dry, a cure may be effected; _in winter_ by feeding the animal from the ground and largely with roots; _and in summer_, by turning out to grass. In either case the matter is allowed to escape almost as soon as formed and the irritated membrane tends to resume its healthy functions. This result will be favored by giving a course of tonics as recommended in _simple ozœna_, and the application of a mild blister to the throat.