_Symptoms._ The disease sets in suddenly, yet prodromata may occasionally be observed, such as dullness, langor, trembling over the flanks and elbows, weakness, prominent, weeping, congested eyes, and low moans when moved. Then follow hyperthermia, at first slight, heat of the mouth without injection, epithelial concretions or erosions and diarrhœa (sometimes there is straining without passage at first). Then follows a period of profuse and fœtid discharge, with relaxed or open anus, the liquids escaping involuntarily and smearing the tail, perineum, thighs and hocks, and the protruded mucosa showing dark red congestions and even commencing erosions. Colicy pains, slight at first, have now become intense, and the right side of the abdomen is very tender to the touch and fluctuates noisily when manipulated. Appetite and rumination are lost. Salivation may be present, the saliva falling in films to the ground. The buccal epithelium is softened, loosened and easily detached by the finger, leaving raw sores. The temperature which has risen slowly (not as in rinderpest abruptly) may reach 106°. The hair becomes dry, the skin harsh, rigid, and firmly adherent to the deeper parts, and often cold, while the muzzle is hot, dry and even cracked. At a still more advanced stage, the pulse is small, the temperature lowered, the animal very weak and unsteady and inclined to lie, great emaciation, sunken glazed eye, drooping head, ears and eyelids, and a general fœtor from the skin as well as the dejections, which attracts crowds of flies. By this time there may be passed only bloody mucus mixed with eschars, and having a most repulsive odor. It is a noticeable fact that the fæces are alkaline, and in man the saliva is acid and destitute of its glycogenic properties, the stomach secretions are alkaline and no longer peptogenic, and the secretion of bile is arrested until improvement sets in. _Course._ _Duration._ Some mild cases recover in two or three days, and in violent cases death may occur at this early date. More commonly the disease continues for two or three weeks before ending in death or recovery. Some merge into the chronic form and may last for months and die in a condition of marasmus. These last cases become mere walking skeletons, with pallid mucosæ, sunken eyes, scurfy hide-bound skins covered with vermin, and the frequently everted rectum is congested and covered with ulcers and eschars. _Mortality_ is _from_ 50 to 80 per cent. _Complications._ Most complications are in the direct line of septic infection. Among the most common are hepatic abscess, gangrenous pneumonia, and extensive gangrene of the intestinal walls. In man arthritis, paralysis, parotitis and other secondary affections are seen. In the animal as well we may expect necrotic centres in any organ, from the supervention of a general septicæmia.