The ammonia which is essential to the precipitation of the phosphate of magnesia in the form of the compound salt (ammonio-magnesian) can be found wherever proteids are in process of septic fermentation. The slightest failure to peptonize every particle of such proteids, implies septic change and the evolution of ammonia, which on coming in contact with magnesia phosphate instantly precipitates the insoluble salt. This fully agrees with the doctrine of the formation of urinary calculi through the agency of bacteria, since the ammonia is essentially a fermentation or bacterial product. It may also be noted that the experiments of Rainey and Ord showed that in the presence of colloids (mucus, epithelium, pus, blood) the earthy salts are precipitated as minute globular bodies which by further accretions become calculi. In the absence of colloids the salts tend to precipitate in angular crystalline forms, so that the mulberry and coralline calculi may possibly have been precipitated in the absence of such bodies. From the solvent quality of ammonia, however, the contents may easily pass from a fermenting liquid containing colloids to a non-fermenting and noncolloid mixture. The presence of a solid body which may act as a nucleus is an essential element, and the condition of the food or drink will often supply this. It has been noticed that army horses in the field, feeding from the ground and taking in sand and pebbles, are unusually liable to intestinal calculus. Horses which lick earth in connection with acidity of the stomach or other dyspepsia are specially subject to it. Horses watered from shallow streams with sandy bottoms, where they take in sand with the water, have been similarly affected. Millers’ horses, in the days of old process milling, suffered not alone because of the abundance of oat hairs in the feed but also on account of the grit from the millstones. Hay and other fodders that have lain on the ground and which contain earth and sand furnish other sources of such nuclei. Shingle nails and other small nails, pins, needles, coins, etc., which have mixed with the feed are common causes of trouble, and indeed any foreign body may become the centre and starting point of a calculus. Catarrhal affections and other lesions of the mucosa, which furnish excess of mucus, beside pus, lymph and even blood as nuclei, are invoked as starting points of the calculi, but however true this may be in particular cases, irritation and catarrh appear to be much more frequently the result than the cause of the calculus.