The more severe forms are ushered in by violent trembling, or by stupor, apathy, and extreme muscular weakness, or actual paralysis. In such cases the animal may stagger or fall. Dysphagia or inability to swallow is often a marked symptom, the saliva falling in strings from the lips. Another common phenomenon is the rigid contraction of the muscles of the neck, back and loins, the parts becoming tender to the touch and a more or less prominent oposthotonos setting in. Twitching of the muscles of the shoulders and flanks may be noticed. Trismus also is sometimes seen. The breathing is usually rapid and catching and the temperature 104° to 106°. The pulse may be accelerated and hard, or weak and soft, or alternating. The eyes are violently congested, of a brownish or yellowish red color, and the eyeballs may be turned to one side. Paroxysms of delirium may set in, when the animal will push against the wall, or perform any of the disorderly movements described under meningo-encephalitis. Sooner or later coma and paralysis supervene, and death occurs in from five to forty-eight hours. In the most acute (fulminant) cases the animal falls and dies in convulsions. On an average the disease lasts from eight to fifteen days. In the more favorable cases, without any supervention of coma, recovery may begin on the third or fourth day. _Symptoms in the_ =Ox=. These are largely those of encephalo-meningitis. If they do not come on with the customary violence, there may be at first difficulty in prehension, mastication and swallowing of food; a rigid condition of the muscles of the neck, back, and sometimes of the jaws, and twitching of the muscles of the limbs, neck, lips, or eyes. For a time there may be hyperæsthesia, restlessness and irritability, stamping of the feet or shaking of the head, then there is liable to follow, dullness, apathy, stupor, coma and paralysis. As in the horse, the distinction from ordinary encephalo-meningitis will at times rest on the prevalence of the epizootic disease in the locality. _Symptoms in_ =Sheep=. The attack is described as coming on with weakness, dullness, lethargy, salivation, convulsions, oposthotonos, grinding of the teeth, succussions of the body and limbs, heat of the head, and stupor or paralysis unless death ensues during a paroxysm. The congestion of the head and of the encephalic mucous membranes, and the deviation of the eyes are constant features. Wischnikewitsch describes an extended outbreak in sheep in which the brain lesions were complicated by hepatization of the lungs, and bacilli were found in the various exudates. This reminds one of the presently accepted cause in man, which is, however, a micrococcus rather than a bacillus.