_Experimentally._ Harnack found that 2 to 3 mgrms. in frogs and 40 mgrms. in rabbits caused increased intestinal peristalsis, diarrhœa, and paralysis of the heart. Dogs had choreic symptoms. Gusserno gave 1.2 grm. to rabbits and dogs respectively, and produced emaciation, shivering and paralysis of the hind extremities. Rosenstein with 0.2 to 0.5 grm. obtained in dogs similar symptoms with epileptiform convulsions, and Heubel had symptoms of colic in a few cases. =Casual or Accidental Poisoning.= Metallic lead is slowly dissolved and therefore large doses of this may be taken in without visible ill effect. Shot has often been given to relieve the symptoms of broken wind in horses, and a dog at the Lyons Veterinary School took four ounces without visible ill effect. When finely divided, however, as in sheet lead or the spray of bullets it presents a much more extended surface to oxygen and acids, and in the acid stomach of monogastric animals, or even in the organic acids of the rumen it is dissolved in quantity sufficient to prove poisonous. _Symptoms in Horses._ Shenton thus describes his cases. “There was a rough, staring coat, a tucked up appearance of the abdomen, and a slightly accelerated pulse; in fact, symptoms of febrile excitement which usually, however, passed away in about a week. About this time large quantities of gray colored matter were discharged from the nostrils, and saliva from the mouth, but at no time was there any enlargement of the submaxillary, lymphatic, or salivary glands. Nor was there constipation of the bowels, which appears to be nearly always present in cases of lead poisoning in man. Fits and partial paralysis came on at intervals; and when the animals got down they often struggled, for a long time ineffectually, to get up again. The breathing up to this time was pretty tranquil, but now became so difficult and labored that the patient appeared in danger of suffocation. The pulse was in no case above 60 or 70, and I ascribe the difficulty of respiration to a paralyzed state of the respiratory apparatus. The animals did not live more than two or three days after these symptoms appeared. The _post mortem_ appearance varied but little. The lungs and trachea were inflamed; the lungs engorged with large quantities of black blood; the trachea and bronchia filled with frothy spume. In all cases but two the villous part of the stomach presented isolated patches of increased vascular action, and in all cases the intestines, and especially the large ones, were inflamed. The blind pouch of the cæcum was nearly gangrenous. There was nothing remarkable about the liver, spleen or kidneys, except that they were of a singularly blue appearance.”