Definition. Predisposing causes: genus, breed, great milking capacity, heredity, mature age, vigor, high feeding, powerful digestion and assimilation, sudden plethora, drying up of milk, parturition, easy delivery, warm season, chills, idiosyncrasy, cardiac hypertrophy, contraction of womb, emotional excitement: Supposed causes: absorption of toxins from womb, colostrum, Schmidt treatment its significance, microbian infection and intoxication, effect of change of stable. Microbiology. Nature: Theories of nervous explosion, vaso-motor cerebral anæmia from exaggerated excitability of the uterine nerves, or from dilatation of the portal system and womb, metro-peritonitis, cerebral anæmia from congestion of the rete mirabile, etc., palsy of the ganglionic nerves, plethora, intracranial arterial tension, narcotic poisons from leucocytic or microbian source. Lesions: variable, cerebral and spinal congestion, pulmonary congestion, collapse, septic inhalation, bronchitis, dessication of ingesta in omasum and large intestine, black thick blood, yellowish gelatinoid exudates in cranium and spinal canal and under spine, glycosuria. Symptoms: time, post parturient, plethoric subject, sudden onset, comatose and violent forms, discomfort, restless movements, inappetence, moaning, mental dullness, unsteady walk, muscular weakness, compulsory recumbency, retained urine and fæces, drowsiness, somnolence, unconsciousness, stertor, venous pulse, tympany, sudden recovery, complete, with paralysis, fatal cases, violence, tossing head, trembling, cramps, convulsions, temperature. Mortality. Prevention: bleeding in plethoric, heavy milkers, purging, low diet, exercise, comfort, milking, blisters, sucking by calf, disinfection, iodine solution in udder. Treatment: in early stages bleeding, purgatives, peristalsis stimulants, antiseptics, injections, stimulants, rubefacients or cold sponging, elevation of the head, udder massage, milking, iodine injection of the mammæ. _Definition._ A nervous disorder which develops suddenly in plethoric cows, heavy milkers, after calving, and is characterized by loss of senses, of consciousness and of muscular control, by hypothermia or hyperthermia, convulsions, coma, and mellituria. _Causes._ While one cannot speak positively as to the essential cause of this disease, certain conditions are so constant and prominent that they must be given a high value as _predisposing causes_.