Upon the preliminary dullness and somnolence there supervenes excitement, manifested by loud bellowing, pushing the horns, forehead or teeth against the wall, labored often stertorous breathing, a fixed eye often with dilated pupil giving it a peculiar glaring appearance, movements of the jaws, frothing at the lips, tremors, muscular spasms, twitching, or a restless disposition to move, in a circle, in a straight line or less frequently backward. The patient seems to see nothing and is utterly regardless of obstacles. Sometimes the animal plunges violently into manger or rack, against or through the partition of his box, through fences, into ponds, pits, quarries and other dangerous places that may be accidentally in his way. The paroxysms may be intermitted by intervals of comparative calm, and tend to merge into a condition of dulled sensation, staggering, stupor, hebetude and paralysis. The congested conjunctiva and, when it can be seen, the optic disc will correspond to the cerebral congestion. These cases usually proceed to a fatal issue in a few hours. Some cases, however, make a good recovery after a few days of dullness and prostration. In cases that are connected with lead poisoning, or the toxic action of narcotics in the fodder, the attendant circumstances will assist in the diagnosis. From malignant catarrh implicating the encephalon, it may be distinguished by the absence of the catarrhal inflammation of the conjunctiva, pituita, sinuses, buccal mucous membrane, and genito-urinary passages. Also of the tendency to implication of the hair follicles and the keratogenous tissue of the frontal horns. In the _Edinburgh Veterinary Review_, Dundas describes a form of alcoholism in cows caused by feeding these animals on “burnt ales” in the vicinity of distilleries. The ale is given by steeping straw in it, and the animals will also drink it freely. They often sleep soundly after such a beverage or give evidence of intoxication. The head is turned singularly to one side and slightly elevated. The pupils are widely dilated, and the eyes have a remarkably wild appearance. On being approached the animals wink rapidly and tremble. There is marked heat of head, horns, and ears. When pressed with the finger in the axilla they fall instantly and when pulled by the head they incline to turn over. The pulse is 70 to 80 per minute. Delirium and loss of coördination of the muscular movements set in, and in case of survival various forms of chronic brain disease are manifested. In one cow the violent symptoms came on with the near approach of parturition. The post mortem lesions consisted in ramified redness and punctiform blood extravasations in the pia mater and meninges. The brain substance was softened and clots of blood were found in the lateral ventricles. Congestion and extravasations were also found around the cervical myelon. (See Alcoholic Intoxication).