The _nervous symptoms_ are especially manifest in the sudden seizure, great prostration, extreme weakness, profound stupor or lassitude, the staggering gait, in bad cases, insensibility to voice, slap or, it may be, even to the whip, the rigidity of the loins, their insensibility to pinching, the difficulty of turning in a short circle, or of backing. The high fever, disproportionate to the appreciable local lesions, and its sudden improvement at the critical period, the excessive weariness and the disposition to lie down contrary to the habit of other inflammatory chest diseases are further indications. This may go on to coma, there may be more or less complete anorexia, muscular trembling, paresis, especially of the hind limbs, or delirious manifestations indicating meningitis. _Rheumatoid attacks of the muscles and joints_ usually appear in the advanced stages of the disease, but may appear earlier. They may occur in any latitude but seem to be especially common in cold, damp, inclement northern regions, and at seasons when climatic vicissitudes are sudden and extreme. These may appear suddenly and disappear with equal rapidity, or they may last for a time during and even after an apparent recovery in other respects. When the joints are involved they usually become engorged with exudates in the synovial membranes. _Lameness_ in either _fore_ or _hind limb_ may assume an _intermittent type_ developed by exercise and subsiding with rest, evidently bespeaking local arterial embolism, and in such cases it is likely to persist for months. A tendency to _transudations_ and _dropsical effusions_ is common in severe cases, showing especially in the filling of the legs, but in certain epizoötics, these become strikingly prevalent and have secured for such a special name (_epizoötic cellulitis_). Apart from the limbs these affect particularly the inferior surface of the chest and abdomen. The swellings are not necessarily hot nor painful nor petechiated as in petechial fever, yet they may merge into that affection or they may become phlegmonous and develop abscess. _Complications_ of many kinds are to be looked for, pregnant mares may _abort_; _laminitis_ may set in; the microbes of _strangles_, _contagious pneumonia_, _cerebro-spinal meningitis_, _septicæmia_, _pyæmia_, etc., may take occasion to attack the debilitated system, and thus complex diseases and manifestations are developed. _Morbid Anatomy._ The lesions may predominate in different organs in different subjects and successive epizoötics. It is a protean disease and may expend its main energy on any one of a number of different organs or systems of organs.