As _vaso-motor_ stimulants have been employed ergot, belladonna, tannic, sulphuric and hydrochloric acids, oil of turpentine, iron sulphate, potassium bichromate and chlorate, quinia sulphate, and strychnia sulphate and arsenate. The value of any one of these is dependent on its early employment, the slight character of the lesions and the remissions that so often occur even in severe attacks. None are of much account in a violent attack at its worst. In the slighter cases _ergotin_, 5 grains daily in two doses, has been apparently useful. An objection is that its continued action on the nerve centres and digestive organs is liable to prove depressing and injurious. Of the acids, _tannic_ is liable to engender constipation, locking up the injurious products to which, however, it acts to some extent as an antiseptic. _Sulphuric_ and _hydrochloric_ acids have a tonic effect, and the latter is a stomachic under ordinary conditions. The same may be said of the _iron salts_ and to some extent of _oil of turpentine_, which have both proved useful in favorable cases. Cadeac condemns ol. terebinth as calculated to abolish kidney secretions. The _potash salts_, _bichromate_ and _chlorate_, and _quinia sulphate_ are decided antiseptics and though the admissible dose would not ensure the destruction of bacteria, yet, acting in the system, with leucocytes and leucomaines, they may serve by keeping them in check. The _chlorate of potash_ is given to the extent of an ounce the first day, and of half an ounce on succeeding days. The _quinine_ salt is given in half ounce doses once or twice daily. In combination with bitters they seem to be of material value. _Nux vomica_ (1 dram) or _strychnia sulphate_ or _arsenate_ (2 grains) given twice daily has seemed to be among the most promising agents of this class. As a potent vaso-motor stimulant, a bitter tonic and stomachic, strychnia has seemed at times to rouse the vitality and enable the system to throw off the load of poison that depresses it. The wonderful power of _adrenalin chloride_ as a vaso-motor stimulant more than warrants its use both locally and generally. In using any one of these agents, we should not neglect concurrent attention to the bowels and kidneys, to antisepsis internally and externally, to hygienic and tonic measures generally. _Antiseptic agents_ have been given by the alimentary canal, the skin, the subcutis, and the air passages. By the _stomach_ the following have proved more or less useful in checking gastro-intestinal fermentations, and perhaps in hindering absorption of toxins from the specific lesions on this track: _phenic acid_, _creolin_, _lysol_, _ichthyol_, _boric acid_, _salicylic acid_, _sodium salicylate_ and _hyposulphite_, and _calomel_.