_Symptoms._ These vary according to the species affected, and the seat of the disease, general or local, _internal_ or _external_. In the latter case the febrile and constitutional disturbance is delayed. In the _internal_ cases the fever is early and of a high type. Even before the animal appears to be seriously ill, while still keeping with the herd and showing life and vigor, there may be high temperature, 104° to 106° F., pulse and breathing accelerated, heart beats tumultuous, tremors or shivering or perhaps only staring coat, anorexia, and grinding of the teeth. Later there may be drooping head and ears, dulness, a disposition to lie, apathy, stupor and somnolence. Nervous excitement and delirium have been noticed. The patient becomes weak, especially behind, comatose, and the temperature declines to, it may be, 97° or even 94° F., prior to death. The visible mucosæ becomes dusky, brownish or yellowish, and streaks of blood may appear in the nose or elsewhere. The urine may be red, the fæces covered with mucus, or blood streaked, and the rectal mucosa of a violet tinge, or blackish and blood gorged. In this the vulvar mucosa often participates. Local swellings may appear in the tongue or pharynx, even if not on the surface, or colics indicate implication of the digestive organs. The examination of the blood early reveals the presence of the bacillus, and as the disease advances, its black, incoagulable, tarry, or coffee-grounds appearance becomes characteristic. Pregnant animals are liable to abort. Death occurs in 12 to 48 hours. Most cases are fatal at the beginning of an outbreak, while later the great majority often recover. _Fulminant cases_ (Anthrax acutissimus) occur mostly in cattle or sheep, in high condition, the victim being found dead in pasture or stall, without previous observation of illness, or, if seen during life there is the sudden attack, leaving food, muscular tremors, anxious expression of countenance, hyperthermia, dyspnœa, dark red mucosæ, it may be streaks of blood on them, plaintive cries, rolling of the eyes, spasms or coma, and death in a few minutes to one or two hours. In _sheep_ there may be separation from the flock, pawing, stretching, shaking of head, turning in circle, dyspnœa, falling, convulsive struggling, passing of blood by nose, kidneys or bowels and death. _Local Anthrax in Cattle. Symptoms._ In _cutaneous anthrax_ the circumscribed swellings appear suddenly, and may grow to considerable dimensions on different parts of the skin, head, neck, breast, shoulders, abdomen, axilla, sheath, udder, or flanks. There may be one or many, and they lack the acute early tenderness, and later crepitation of black quarter. On white skins they are dark red, or violet, and when incised, show a gelatinoid, bloody, non-suppurating mass, abounding in bacilli.