Over a year and a half ago it was suggested by Prof. H. P. Bowditch
that if some substance opaque to the Röntgen rays were swallowed,
it could be seen in its passage to the stomach, and the nature of
its movement thus determined. Anæsthesia could be dispensed with,--a
desirable condition, since observers had found that it interfered
greatly with the deglutition reflex. It would be unnecessary to open
either the abdominal or the pleural cavity. The reflex stimulus of
food, moreover, would be better than electrical stimulation of the
superior laryngeal nerve. In short, the animal would swallow normal
food under practically normal conditions. At Dr. Bowditch’s suggestion
and with his valuable assistance--which we gratefully acknowledge--we
made the following series of experiments.
To render the swallowed mass opaque, subnitrate of bismuth was used.
The salt is tasteless, practically inert, and can be fed in large
quantities without harm. In order that observations could be made by
more than one person, all experiments were conducted in a dark room. On
the side of the animal opposite the Crookes tube was placed an open
fluorescent screen, on which the different tissues of the animal were
outlined with varying degrees of light and shade. Among these shadows
the swallowed mass appeared as a darker object, and thus its motion
could be studied.
For the first experiments the goose was selected. The head and neck
were held stationary by a tall pasteboard collar, which allowed free
movement of the head without constriction of the neck. The fluorescent
screen was placed against this collar at a uniform distance of thirty
centimetres from the tube. When a bolus of corn-meal mush mixed with
bismuth was placed in the pharynx, it descended slowly and regularly,
and occupied about twelve seconds in passing over a distance of fifteen
centimetres. The screen was marked at intervals of two centimetres with
cross lines, by means of which the relative rate in different parts of
the œsophagus could be studied. A vibrator marking tenths of a second
was interrupted whenever the bolus crossed a line. An average of over
one hundred such observations showed that the rate became slightly
slower as the bolus proceeded.
In order to test liquids, molasses was mixed with bismuth to such a
consistency as to drop easily from a glass rod. When this was fed
with a pipette, it passed slowly and regularly down the œsophagus,
clearly by peristalsis. The rate was about the same as for solid food.
In both these experiments the addition of water would sometimes cause
irregularities in the descent. Microscopic sections from four different
parts of the œsophagus of the goose showed no histological difference.
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