The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economyHeadland, Frederick William
Science
The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economy
Headland, Frederick William
Therapeutics
Should this be the case, the great affinity existing between the course
and symptoms of Gout and Rheumatism would be easily explained, there
being in both disorders an impediment to the proper oxidation of lactic
into carbonic acid. These things may be illustrated by a diagram,
showing the results which are supposed to take place when the natural
process is arrested at, or diverted from, any of its stages:--
Starch.
|+
|2
|a
|q
|=
Grape Sugar (Diabetes.)
|
|\
| \
| \+ O =
| \
| \
| \ Oxalic acid. (_Oxaluria._)
|
|=
Lactic acid (Rheumatism.)
|
|\
| \
| \+ 2 Urea + O 6 =
| \ Uric acid + 10 aq. (_Gout, and Lithiasis._)
|+
|O
|=
Carbonic acid.
Thus, at each of the two transitional stages, we might have one diseased
condition produced by an arrest of the process, and another by its
deviation. These deviations and stoppages may result from a failure of
some natural principle which is gifted with the control and direction
of the series of transformations; or they may simply be traceable to a
want of vital energy, or nervous force.
The same ideas may be more distinctly expressed by a few chemical
equations.
_Natural process._
C_{12}H_{10}O_{10} + 2 HO = C_{12}H_{12}O_{12}.
= 2 (C_{6}H_{5}O_{5}, HO.)
C_{6}H_{6}O_{6} + O_{12} = 6 CO_{2} + 6 HO.
_Oxaluria._
C_{12}H_{12}O_{12} + O_{18} = 6 C_{2}O_{3} + 12 HO.
_Gout and Lithiasis._
Lactic acid + 2 Urea + O_{5} = Uric acid + 10 HO.
The last equation may be thus proved at length:--
C_{6} H_{6} O_{6}. C_{10}H_{4} O_{6} N_{4}.
C_{4} H_{8} O_{4} N_{4}.
O_{6}. H_{10}O_{10}.
------------------------ ------------------------
C_{10}H_{14}O_{16}N_{4}. = C_{10}H_{14}O_{16}N_{4}.
It is next to be inquired how far the theoretical explanation of these
diseases which has thus been sketched out can be applicable to the
matter in which we are more immediately interested, viz., the action of
the Catalytic remedies used to cure them.
For the radical cure of Diabetes there is no known remedy; though some
relief may be afforded by a system of dieting. (_Vide Aliments._) It is
supposed that what we have to do is to convert diabetic sugar, _i.e._
grape-sugar, into lactic acid. This acid probably exists in the gastric
juice. And some such substance as Pepsin, or the decomposing Caseine in
sour milk, which is capable of effecting this change out of the body,
might perhaps avail us, if we could contrive to introduce it into the
blood.
Public-domain text, read in full here on John Shaqi.
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