The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economyHeadland, Frederick William
Science
The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economy
Headland, Frederick William
Therapeutics
Some space and labour was required in the proof of the minor
propositions relating to Hæmatics, for among them were included some
things that are not universally acknowledged; but the above account of
the action of Neurotics concerns matters that are very generally
admitted, and will not occupy us nearly so long in its discussion.
In the first place it is affirmed that Neurotic medicines pass into the
blood. In the consideration of Prop. II., it was shown that all of
them,--whether vegetable alkaloids, volatile oils, resins, or mineral
substances,--were more or less capable of being absorbed. That they do
pass into the blood is proved by the fact that many of them have been
detected there, as well as found in the secretions into which they must
have entered from the blood. Ammonia, Hydrocyanic acid, Antimony,
Assaf[oe]tida, Turpentine, Alcohol, and Camphor,--all of which are
Neurotic agents,--have been chemically detected in the blood by
Tiedemann and Gmelin. A still larger number have been discovered in the
urine by Wöhler, particularly of volatile oils and odorous principles.
The active principles of Opium, Belladonna, Stramonium, and Henbane,
have been detected in the same secretion by others.
Thus Neurotics pass into the blood. That they act after this absorption,
and not by contact with the mucous surface, was proved in the
consideration of Prop. I.
The second minor proposition is borne out even by the names by which the
recognised action of these medicines is distinguished. Considered as a
class, they have no action on the blood, but their influence is quickly
and obviously exerted on the nervous system, or on the vital functions
which are universally attributed to that part of the animal frame.
Stimulants are so called because they are found by experience to exalt
nervous force; Sedatives, because they depress it. Thus Ammonia is given
to prevent Syncope, caused by a weakness or failure in power of the
nerves of the heart; and Aconite is prescribed to relieve pain caused by
an over-excitement of the sensory nerves. Though in these examples
Ammonia acts on the centre, and Aconite on the peripheral nerves, yet
they are both capable of exalting or of depressing nervous force in
general. But neither Stimulants nor Sedatives, as defined by me, exert
any marked influence on the intellectual part of the brain. They do not
affect the phenomena of mind, or of the four special senses which are
immediately associated with it. This influence is confined to the
intermediate division of Nerve-medicines, called Narcotics. Their
general action is evidenced by a short or long primary stimulation,--and
a subsequent depression of nervous force, which is also of variable
intensity. At the same time they affect the mind in various ways;
exciting it, confusing it or lulling it. Opium and Alcohol are examples
of Narcotics. These distinctions are in most cases obvious and well
defined.[42]
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