The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economyHeadland, Frederick William
Science
The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economy
Headland, Frederick William
Therapeutics
Administered internally in solution, it has a power of quickening the
action of the heart, and exciting the circulation generally. It is
therefore particularly useful in the common case of fainting, or
threatened syncope. This stimulant power is possessed only by the free
alkali and its carbonates. And as the secretion of the stomach is acid,
Dr. Pereira supposes that the free or carbonated Ammonia becomes
neutralized before absorption; that it is therefore unable to act in the
blood except as a salt, and can only operate as a Stimulant while in
contact with the coat of the stomach. Its influence must then be
conducted by the nerves from the surface of the stomach to the heart.
But though the nerves are the natural channels of various motor and
sensory impressions, it is to assume an unprecedented thing to suppose
that a medicinal action can be transmitted by their means to a distant
part. For this and for other reasons it seems to me to be most likely
that the solution of Ammonia is absorbed too fast in the stomach to be
neutralized by the gastric juice. Or even if it were neutralized before
absorption, it would probably be again set free on entrance into the
blood, in which there is a slight excess of alkaline matter. Thus
Ammonia would exist in the blood in a free state, except in those morbid
conditions in which there is a general excess of acid in the system. I
suppose the same to be the case with Potash, when it is given in any
quantity. The great diffusibility of the free Ammonia would be an
additional reason for its rapid absorption. When the gas is inhaled, as
in the use of smelling-salts, and applied thus to the nasal and
pulmonary mucous membranes, it must pass through to the blood in a free
state, for these surfaces do not secrete an acid. And yet its effects in
this case are the same as when it is taken into the stomach, which
further renders it probable that in the latter instance it is absorbed
free.
When there is an excess of acid in the system, Ammonia may be used as a
Restorative. It diminishes the acid reaction of the secretions by
combining with the acid to form a salt.
In ordinary conditions (_i.e._ when not required in the system) it has
to be excreted from the blood. Both Ammonia and its salts act as
Expectorants and Diaphoretics, being excreted on the mucous surface of
the lungs, and on the skin. Free Ammonia is a better Expectorant than
any of its neutral salts. The secretion of sweat contains an acid. The
Ammonia which passes out on the skin combines with this acid. But on the
pulmonary surface it is probably excreted free. For it is found that the
careful inhalation of Ammoniacal gas has the same effect in augmenting
the mucous secretion as the internal use of Ammonia. Ammonia is
volatile, and soluble in air; and tends for that reason to pass off
freely from those secreting surfaces which are immediately in contact
with the atmosphere. (p. 278.)
Public-domain text, read in full here on John Shaqi.
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