The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economyHeadland, Frederick William
Science
The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economy
Headland, Frederick William
Therapeutics
But we have now only to regard the gastric juice as containing a free
acid. This would reduce to solution the carbonates and oxides of all the
metals; less perfectly when anhydrous, more easily when in the hydrated
form. In this manner are absorbed the oxides of Iron and Silver, the
carbonates of Lime and Magnesia, and other medicines of the same kind.
They would be slightly modified, being absorbed in combination with the
(lactic) acid of the stomach. In this they would differ somewhat from
the substances already soluble, which would probably be absorbed
unchanged, unless we except the alkalies and their carbonates, which
might be similarly decomposed. Even these, if given in solution, would
probably be absorbed faster than the gastric acid could be secreted to
neutralize them.
Other insoluble substances, such as calomel and metallic sulphurets,
would be more or less dissolved by the action of this acid. But as a
great part would necessarily escape its influence, being propelled
onwards by the muscular contraction of the stomach, it follows that
insoluble substances of this kind are much less active as medicines than
similar compounds introduced in a soluble state. It is also likely that
a certain quantity would be sufficient to exhaust for a time the acid
gastric secretion.
We now pass on to a third class of mineral products, which, though
insoluble both in water and in acid, yet, being soluble in alkalies,
appear to be in this way prepared by absorption.
3. Mineral bodies insoluble in water and in acid, but soluble in
alkalies.--These remain unaffected by the action of the gastric juice,
but on passing on as far as the centre of the duodenum, they meet with
two alkaline fluids. These are the bile and the pancreatic juice. We
know that some such insoluble bodies pass into the blood. It will be
shown in the proof of the next Proposition, that they cannot do so
without being first dissolved. Therefore, there must be in the
intestinal canal something capable of thus dissolving them. For this
purpose these two alkaline secretions are well adapted. As an example of
such mineral bodies, of which there are not many, I may adduce sulphur.
It unquestionably passes into the blood, and is found there in
combination with alkalies, as a sulphuret or sulphate. It has been
detected in the urine of those who were taking it, by Dr. Ronalds and
others. It is possible that iodine, bromine, and some of the hydrated
metallic oxides; may enter the blood in the same way.
4. Vegetable substances soluble in water.--These would be absorbed with
more or less readiness according to their degree of solubility. They
would probably be taken up in great part by the stomach. Some vegetable
matters--as Lignine, or woody fibre, and Resins--are insoluble in water.
Starch even is comparatively insoluble, and thus comes under another
division, being probably one of those vegetable substances which are
rendered soluble by the aid of the pepsin of the gastric juice.
Public-domain text, read in full here on John Shaqi.
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