The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economyHeadland, Frederick William
Science
The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economy
Headland, Frederick William
Therapeutics
These soluble vegetable matters are of several kinds. Cane-sugar and
grape-sugar are readily soluble. So also are the various vegetable
acids. There is another class of bodies which is highly important in a
medical point of view. These are the natural salts of the vegetable
alkaloids, of which are constituted so many of the active principles of
plants. In pharmaceutical operations we are enabled, by the judicious
employment of different menstrua, to extract from the crude and inert
mass these vegetable active principles, and thus to obtain in a
concentrated form the medicinal power for which each plant is esteemed.
This process is also performed in the stomach. By digestion and
concoction, with or without the aid of acid, it is enabled to dissolve
out these soluble and potent matters from the ligneous and bulky tissues
which surround them. For though the alkaloids themselves are in general
almost insoluble in water, yet their natural salts which occur in the
vegetable kingdom are mostly very soluble. The most important of these
salts are as follow. In Cinchona bark, the Kinates of Quina and
Cinchonia. In Opium, the Bimeconates of Morphia and Codeia. In Nux
Vomica, the Igasaurate of Strychnia. In Aconite, the Aconitate of
Aconitina. In Colchicum and Sabadilla, the Supergallates of Colchicia
and Veratria. There are some neutral soluble substances, not partaking
of the nature of Alkalies. Thus we find in Ipecacuanha and Ionidium,
Emetine; in Tea and Coffee, Caffeine; in Willow-bark, Salicine; and the
soluble active principles of Senna, Aloes, and Gentian, are probably of
the same nature. Many other alkaloids are known. Atropia in Belladonna,
Daturia in Stramonium, and Hyoscyamia in Hyoscyamus, occur in
combination with Malic acid. Conia in Hemlock, and Nicotia in Tobacco,
are peculiar volatile alkalies containing no Oxygen: thus in two
respects they resemble Ammonia. They too are soluble in water.
Alcoholic and Ethereal fluids may be enumerated here as soluble
products of the vegetable kingdom. Alcohol mixes with water to any
extent; and one part of Ether is soluble in ten parts of water. Nitric
Ether and Chloroform are also sufficiently soluble. So is Creosote, 1.25
parts of which dissolve in 100 of water. But this may be absorbed in
another way, as will be seen presently. Volatile Oils and Turpentine
come also under this head. They are all slightly soluble in water. The
former, when given in small doses, are probably absorbed in this way.
Turpentine, when given in large doses, may perhaps, by undergoing a
change, come under the head of vegetable substances dissolved by
alkalies. Camphor may be included here: one part is soluble in 1000
parts of water.
The soluble gummy matters of plants, when added to the substances
enumerated above, constitute an aggregate which is called the _watery
extractive_ of a vegetable product: _i.e._ that part which is capable of
being dissolved out of it by pure water.
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