The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economyHeadland, Frederick William
Science
The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economy
Headland, Frederick William
Therapeutics
6. We have already considered some few mineral substances which are
absorbed by the aid of the free alkali contained in the Biliary and
Pancreatic secretions.[26] The sixth kind of absorbed matters consists
of some vegetable and animal products which can only be rendered soluble
by a similar agency. Fats and oils, resinous matters, and some
principles resembling resins, come under this head. Fats and fixed oils
consist of acids, as Stearic, Margaric, and Oleic, insoluble in water,
in combination with a base, Glycerine, which, when isolated, is soluble.
With a free alkali such a fat forms a soluble salt, called a soap, and
the base Glycerine is set free.
In Man the Bile and Pancreatic juice are discharged together into the
middle of the Duodenum. The fatty matters of the food are not absorbed
before they meet with these secretions. But, after they have mixed with
them, a milky fluid, called chyle, is formed, which is then taken up by
the lacteal absorbents. It passes thence into the Thoracic duct, meeting
there with an albuminous lymph, and is discharged at length into the
general circulation at the junction of the left jugular and subclavian
veins.
M. Bernard, in some papers laid lately before the French Academy,
states, as the result of his experiments, that the function of the
Pancreatic juice is to reduce the fat to the condition of a white
emulsion. He states that no milky chyle is formed when the Pancreatic
ducts are tied in dogs. He considers it absolutely necessary that
saccharine and albuminous matters should be absorbed by the capillaries
of the Portal veins, and then pass through the liver; and believes that
the sole function of the lacteals is to take up fat thus emulsified. His
experiments and inferences have received the high sanction of M.
Magendie.
M. Frerichs has since affirmed that, whatever be the function of the
Pancreatic juice, the Bile, by virtue of the alkali which it contains,
is an indispensable agent in the absorption of fats. But M. Bernard has
also found that the Pancreatic juice is always alkaline in health.
Whatever be the particular function of the Bile, it may reasonably be
concluded that the alkali contained in one or both of these fluids is
engaged in the saponification and solution of the emulsified fats. If it
were not for this, this alkali would seem without an object; and
further, it is contrary to all we know of the process of absorption to
suppose that oil could pass through to a watery fluid without the
intervention of an alkali to reduce it to the soluble state.
Thus it would seem likely that by means of the Pancreatic juice, with or
without the aid of the Bile, fatty matters are first emulsified, in
order to undergo an increase of surface, and then again saponified
before they can be absorbed by the lacteal villi.
Public-domain text, read in full here on John Shaqi.
Reviews
Reviews
No reviews yet
Be the first to share your thoughts on this work.
Elsewhere in the archive
Join the Discussion
Join the discussion
Sign in to leave a comment or review.
Sign InorCreate an account