The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economyHeadland, Frederick William
Science
The Action of Medicines in the System: Or, on the mode in which therapeutic agents introduced into the stomach produce their peculiar effects on the animal economy
Headland, Frederick William
Therapeutics
But there are other active parts of vegetables, such as oily and
resinous matters, and some neutral acrid principles, which, before they
can be dissolved by water, require the aid of an alkali. These will be
considered separately.
We now arrive at a fifth class of matters which are taken up by
absorption.
5. Animal and vegetable products dissolved by the gastric juice.--The
most important of these are the nitrogenous and nutritive constituents
of the flesh of animals and of the parts of vegetables. Albumen,
Glutine, Fibrine, and Caseine, are connected together as compounds of
Proteine. Animal Fibrine, and the analogous Glutine of vegetables, are
quite insoluble in water. Albumen and Caseine, though soluble, are
immediately precipitated by acids. This is known to be at first effected
by the gastric juice on their entry into the stomach. But the action of
the gastric juice which contains an acid, and a peculiar nitrogenous
material called Pepsin,--together with the temperature of the body,
which is about 100°,--causes at length the gradual solution of these
previously insoluble matters. This is found to take place out of the
body when the above conditions are imitated with an artificial gastric
fluid. The result of the process is a viscid fluid, which is then
absorbed. The hard Gelatine of gristle and bone is not soluble in water
at this temperature, but is readily soluble in the acid gastric juice.
The Pepsine seems to be an important agent in this process, for an acid
by itself is found to produce an imperfect solution. The nitrogenous
matters thus digested and absorbed constitute that portion of the food
which is of most use in the nutriment of the system; for the starchy
compounds cannot be appropriated to the more solid tissues, although in
some cases they may be converted into fat, as in herbivorous animals.
(Liebig's _Animal Chemistry_, p. 113.)
Starch itself is one of this class. Tiedemann and Gmelin found that by
the action of the gastric juice it was slowly converted into Dextrine,
which afterwards changed into grape sugar. Both of these are very
soluble. From the researches of Bouchardat and others, it appears that
other fluids, as the Saliva, the secretion of Brunner's glands, and the
Pancreatic juice, possess also this power of converting starch into a
more soluble compound. So that if any of it escape the action of the
stomach-secretion, it is probably reduced to solution and absorbed in
the small intestine.
This change of starch is the first of a series of transformations, now
ascertained, the ultimate result of which is its combustion and
resolution into carbonic acid. Thus the nitrogenous compounds are called
the _nutritive_, and the starchy materials the _calorifacient_ elements
of the food. Considered as medicines, these substances belong to the
division of Aliments.
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