_The Large Intestine._ The planes of the two sections studied are shown in Figure 35; a low-power drawing of the posterior region is shown in Figure 52. The anterior and posterior regions of the large intestine do not differ from each other sufficiently to make it worth while to represent both by drawings. Had an entire section through either region been drawn it would be seen that the wall is of very different thickness in different places, as was noted in connection with the small intestine; the posterior section was drawn where the wall was thin. It might be supposed that in the feeding season the fecal matter in the posterior region of the rectum would stretch the walls sufficiently to obliterate largely the prominent folds seen in Figure 52, but such does not seem to be the case. The usual layers of the vertebrate intestine are present. [Illustration: FIG. 53. The epithelium of the anterior region of the rectum of the hibernating animal, under high magnification; _e_, epithelium; _tp_, tunica propria.] The epithelium, shown under high magnification in Figure 53, is of the same character and thickness throughout, except that as the anal aperture is approached the columnar epithelium changes into the stratified variety. It consists of very tall and narrow columnar cells apparently in one layer, though it is difficult to be sure of this. With an occasional exception, near the top, all of the nuclei are arranged in a fairly wide zone below the middle of the epithelium. The nuclei are oval in shape and lie so close together that it is difficult, as has been said, to be sure that the cell to which each belongs extends throughout the entire thickness of the epithelium. Beneath the epithelium (Fig. 52, _e_) is a dense tunica propria, _tp_, underlaid, in turn, by the muscularis mucosa, _mm_, and a submucosa, _sm_, of the usual character, which is thrown into marked folds. The circular, _cm_, and longitudinal, _lm_, layers are of the usual character except that they vary more in thickness, as noted above, and in density than is usually the case. The serosa, _s_, is comparatively thin and compact in both regions, and varies somewhat in thickness at different places. The large intestine of the feeding animal was sectioned in the same regions as in the hibernating. As has been said, the feeding animals used were much smaller than the hibernating, so that, as might be expected, the diameter of the large intestine was much less in the former than in the latter. Except for this difference in diameter there was no noticeable difference between the two stages. In the case of the small intestine, it will be remembered, the greater diameter of the intestine of the larger animal was mainly due to the greater thickness of the muscular and connective-tissue layers and not to any increase in thickness of the mucous membrane. In the large intestine the mucosa varies in thickness in the animals of different size as do the other layers of the wall.