“It happened in the year 1790, that his wife, being consumptive, was advised to take, as a nutritive article of diet, some soup made of the flesh of frogs. Several of these animals, recently skinned for that purpose, were lying on a table in the laboratory, close to an electrical machine, with which a pupil of the Professor was amusing himself in trying experiments. While the machine was in action, he chanced to touch the bare nerve of the leg of one of the frogs with the blade of the knife that he held in his hand; when suddenly the whole limb was thrown into violent convulsions. Galvani was not present when this occurred, but received the account from his lady who had witnessed, and had been struck with the singularity of the appearance. He lost no time in repeating the experiment: in examining minutely all the circumstances connected with it, and in determining those on which its success depended. He ascertained that the convulsions took place only at the moment when the spark was drawn from the prime conductor, and the knife was at the same time in contact with the nerve of the frog. He next found that other metallic bodies might be substituted for the knife, and very justly inferred that they owed this property of exciting muscular contractions to their being good conductors of electricity. Far from being satisfied with having arrived at this conclusion, it only served to stimulate him to the farther investigation of this curious subject; and his perseverance was at length rewarded by the discovery, that similar convulsions might be produced in a frog, independently of the electrical machine, by forming a chain of conducting substances between the outside of the muscles of the leg, and the crural nerve. Galvani had previously entertained the idea, that the contractions of the muscles of animals were in some way dependent on electricity; and as these new experiments appeared strongly to favour this hypothesis, he with great ingenuity applied it to explain them. He compared the muscles of a living animal to a Leyden phial, charged by the accumulation of electricity on its surface, while he conceived that the nerve belonging to it, performed the function of the wire communicating with the interior of the phial, which would, of course, be charged negatively. In this state, whenever a communication was made by means of a substance of high conducting power between the surface of the muscle and the nerve, the equilibrium would be instantly restored, and a sudden contraction of the fibres would be the consequence.