In a subsequent number of the same work we find the subject resumed; from which able production we select the following:-- "The suppression of perspiration has at all times been thought to have a good deal to do with the production of disease. Without doubt this has been exaggerated. But, allowing this exaggeration, is it not admitted by all practitioners that causes which act through the medium of the skin are susceptible, in sufficient degree, of being appreciated in the circumstances ushering in the development of very many diseases, especially those characterized by any active flux of the visceral organs? For example, is it not an incontestable pathological fact, that catarrhal, bronchial, pulmonic, and pleuritic affections, congestions of the most alarming description in the vascular abdominal system of the horse, inflammation of the peritoneum and womb following labor, catarrhal inflammations of the bowels, even congestions of the feet, &c., derive their origin, in a great number of instances, from cold applied to the skin in a state of perspiration? What happens in the organism after the application of such a cause? Is its effect instantaneous? Let us see. Immediately on the repercussive action of cold being felt by the skin, the vascular system of internal parts finds itself filled with repelled blood. Though this effect, however, be simply hydrostatic, the diseased phenomena consecutive on it are far otherwise. "It is quite certain that, in the immense system of communicating vessels forming the circulating apparatus, whenever any large quantity of blood flows to any one particular part of the body, the other vessels of the system must be comparatively empty.[14] The knowledge of this organic hydrostatic fact it is that has given origin to the use of revulsives under their various forms, and we all well know how much service we derive from their use. "But in what does this diseased condition consist? Whereabouts is it seated? "The general and undefined mode it has of showing its presence in the organism points this out. Immediately subsequent to the action of the cause, the actual seat of the generative condition of the disease about to appear is the blood; this fluid it is which, having become actually modified in its chemical compositions under the influence of the cause that has momentarily obstructed the cutaneous exhalations, carries about every where with it the disordered condition, and ultimately giving rise, through it, to some local disease, as a sort of eruptive effort, analogous in its object, but often less salutary in its effect; owing to the functional importance of the part attacked, to the external eruptions produced by the presence in the blood of virus, which alters both its dynamic and chemical properties.