To cure, by means of stimuli, a complaint which arose from an over-indulgence in such agents, is apparently paradoxical; but experience confirms the propriety of the practice where, _a priori_, we might expect the contrary. In the second variety of the disease, the same objections do not apply to blood-letting as in the first, but even there, great caution is necessary, especially if the disease has gone on for any length of time, if the pulse is quick and feeble or the tongue foul. At first, general blooding will often have an excellent effect, but should we not be called till after this stage it will prove a hazardous experiment. Local blooding will then sometimes be serviceable where general blooding could not be safely attempted. The patient should be purged well with calomel, have his head shaved, and kept cool with wet cloths, and sinapisms applied to his feet. When the bowels are well evacuated, and no symptoms of coma exist, opiates must be given as in the first variety, but in smaller and less frequently repeated doses. Much yet remains to be known with regard to the pathology of delirium tremens. I believe that physicians have committed a dangerous error, in considering these two varieties as modifications of the same disease. In my opinion they are distinct affections and ought to be known under different names. This cannot be better shown than in the conflicting opinions with regard to the real nature of the disease. Dr. Clutterbuck, having apparently the second variety in his eye, conceives that delirium tremens arises from congestion or inflammation of the brain; while Dr. Ryan, referring to the first, considers it a nervous affection, originating in that species of excitement often accompanying debility. It is very evident, that such different conditions require different curative means. The genuine delirium tremens is that described under the first variety, and I agree with Dr. Ryan in the view he takes of the character of this singular disease.