It seems probable that, in plethoric subjects, the habit of drunkenness might be attacked with some success by the application of leeches, cold applications and blisters to the head, accompanied by purgatives and nauseating doses of tartar emetic. Dr. Caldwell of Lexington, conceives drunkenness to be entirely a disease of the brain, especially of the animal compartments of this viscus, and more especially of that portion called by phrenologists the organ of _alimentiveness_, on which the appetite for food and drink is supposed mainly to depend. Should his views be correct, the above treatment seems eligible, at least in drunkards of a full habit of body, and in such cases it is certainly worthy of a full trial. I refer the reader to Dr. Caldwell’s Essay, in which both the above doctrine and the practice founded upon it are very ably discussed. It is, indeed, one of the ablest papers which has hitherto appeared upon the subject of drunkenness.[42] It very often happens, after a long course of dissipation, that the stomach loses its tone, and rejects almost every thing that is swallowed. The remedy, in this case, is opium, which should be given in the solid form in preference to any other. Small quantities of negus are also beneficial; and the carbonate of ammonia, combined with some aromatic, is frequently attended with the best effects. When there is much prostration of strength, wine should always be given. In such a case the entire removal of the long-accustomed stimulus would be attended with the worst effects. This must be done gradually. Enervated drunkards will reap much benefit by removing to the country, if their usual residence is in town. The free air and exercise renovate their enfeebled frames; new scenes are presented to occupy their attention; and, the mind being withdrawn from former scenes, the chain of past associations is broken in two. Warm and cold bathing will occasionally be useful, according to circumstances. Bitters are not to be recommended, especially if employed under the medium of spirits. When there is much debility, chalybeates will prove serviceable. A visit to places where there are mineral springs is of use, not only from the waters, but from the agreeable society to be met with at such quarters. The great art of breaking the habit consists in managing the drunkard with kindness and address. This management must, of course, be modified by the events which present themselves, and which will vary in different cases.