Of retention and evacuation, there be divers kinds, which are either concomitant, assisting, or sole causes many times of melancholy. [1466] Galen reduceth defect and abundance to this head; others [1467]All that is separated, or remains. _Costiveness_.] In the first rank of these, I may well reckon up costiveness, and keeping in of our ordinary excrements, which as it often causeth other diseases, so this of melancholy in particular. [1468]Celsus, lib. 1. cap. 3, saith, It produceth inflammation of the head, dullness, cloudiness, headache, &c. Prosper Calenus, lib. de atra bile, will have it distemper not the organ only, [1469]but the mind itself by troubling of it: and sometimes it is a sole cause of madness, as you may read in the first book of [1470]Skenkius's Medicinal Observations. A young merchant going to Nordeling fair in Germany, for ten days' space never went to stool; at his return he was [1471]grievously melancholy, thinking that he was robbed, and would not be persuaded but that all his money was gone; his friends thought he had some philtrum given him, but Cnelius, a physician, being sent for, found his [1472]costiveness alone to be the cause, and thereupon gave him a clyster, by which he was speedily recovered. Trincavellius, consult. 35. lib. 1, saith as much of a melancholy lawyer, to whom he administered physic, and Rodericus a Fonseca, consult. 85. tom. 2, [1473]of a patient of his, that for eight days was bound, and therefore melancholy affected. Other retentions and evacuations there are, not simply necessary, but at some times; as Fernelius accounts them, Path. lib. 1. cap. 15, as suppression of haemorrhoids, monthly issues in women, bleeding at nose, immoderate or no use at all of Venus: or any other ordinary issues. [1474]Detention of haemorrhoids, or monthly issues, Villanovanus Breviar. lib. 1. cap. 18. Arculanus, cap. 16. in 9. Rhasis, Vittorius Faventinus, pract. mag. tract. 2. cap. 15. Bruel, &c. put for ordinary causes. Fuchsius, l. 2. sect. 5. c. 30, goes farther, and saith, [1475]That many men unseasonably cured of the haemorrhoids have been corrupted with melancholy, seeking to avoid Scylla, they fall into Charybdis. Galen, l. de hum. commen. 3. ad text. 26, illustrates this by an example of Lucius Martius, whom he cured of madness, contracted by this means: And [1476] Skenkius hath two other instances of two melancholy and mad women, so caused from the suppression of their months. The same may be said of bleeding at the nose, if it be suddenly stopped, and have been formerly used, as [1477]Villanovanus urgeth: And [1478]Fuchsius, lib. 2. sect. 5. cap. 33, stiffly maintains, That without great danger, such an issue may not be stayed. Venus omitted produceth like effects. Mathiolus, epist. 5. l. penult., [1479]avoucheth of his knowledge, that some through bashfulness abstained from venery, and thereupon became very heavy and dull; and some others that were very timorous, melancholy, and beyond all measure sad.